The reactions of oximes to amides, known as the Beckmann rearrangement, may undergo fragmentation to form carbocations nitriles when the migrating groups have reasonable stability as cations. The reactions of oxime sulfo...
A series of simple chiral primary amino acids were first successfully applied to promote the enantioselective alpha-amination of branched aldehydes with azadicarboxylates and the desired adducts bearing quaternary stereo...
A mild, simple process for the effective deoximation of a wide range of ketoximes and aldoximes has been developed, which utilizes available NaNO2 as the catalyst and molecular oxygen as the green oxidant. Notably Amberl...
Stepwise, selective DIBAL reduction of the acetonide diester derived from tartaric acid followed by the Horner-Emmons reaction effectively provided desymmetrized hydroxy mono-olefination products in a one-pot operation.
Efficient synthesis of enantiopure polyfluoroalkanesulfinamides (PFSAs) has been achieved. Their application as novel chiral auxiliaries with an electron-withdrawing and F-19 NMR monitorable polyfluoroalkyl group was ini...
Two stable supramolecular loops (1 and 2) were successfully constructed by the molecular recognition of cucurbit[8]uril (CB[8]) and the homoditopic bispyridiniurn derivatives (3 and 4). Interestingly, the interconversion...
A convenient method for preparing substituted anilines via a Rh-catalyzed [2 + 2 + 2] cycloaddition reaction of diynes and 2-oxazolone was discovered. The initial cycloaddition adducts undergo facile decarboxylation of c...
In this paper, a novel and applicable synthesis of benzofurans from commercially available phenols and propiolate through the direct oxidative cyclization has been developed. In the presence of Pd(OAc)(2)/PPh3 and CF3CO2...
Copper iodide has been shown to be an effective cocatalyst for the olefin cross-metathesis reaction. In particular, it has both a catalyst stabilizing effect due to iodide ion, as well as copper(I)-based phosphine-scaven...
An expedient protocol for synthesis of orthogonally protected 2-azido-2-deoxy-D-glucosamine and 2-azido-2-deoxy-D-galactosamine donors from D-mannose is described. Readily available phenyl,beta-D-thiomannoside is rapidly...
The synthesis of 1,2-disilylethanes [R1R2R3Si-(CH2)(2)SiR1R2R3] is usually conducted by using noble metal reagents or catalysts. This work describes a new electrochemical synthetic method for their preparation in good yi...
Ionic diamine rhodium complex (1) catalyzes the reductive N-cyclization of 2-vinylnitroarenes using carbon monoxide as a reducing agent to afford functionalized indoles. The catalytic system allows direct access to indol...
To gain access to 3-propoxy-beta-carboline hydrochloride (3-PBC center dot HCl) (1 center dot HCl) and beta-carboline-3-carboxylate-tert-butyl ester (beta CCt) (2), potential clinical agents active against alcohol self-a...
We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cydization, an...
A general and efficient procedure for the synthesis of functionalized 5-azaindoles through the catalyzed heteroannulation of 4-acetamido-3-iodopyridines and diaryl-alkynes is described. The reaction allows the preparatio...
CuO nanospindles have been developed to efficiently catalyze the direct arylation of heterocycle C-H bonds with moderate to excellent yields. This reaction can be applied to heterocycles such as benzoxazole, benzothiazol...