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Multicomponent Synthesis of Fused Benzimidazolopiperazines

  作者 EL KAIM LAURENT; GRIMAUD LAURENCE; PURUMANDLA SRINIVAS REDDY  
  选自 期刊  Journal of Organic Chemistry;  卷期  2011年76-11;  页码  4728-4733  
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[摘要]We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cydization, an intramolecular reductive cyclization, and an oxidation.

 
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