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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共86条记录   Structural Dynamics of Bacterial Translation Initiation Factor IF2 [作者：Wienk, H; Tishchenko, E; Belardinelli, R; Tomaselli, S; Dongre, R; Spurio, R; Folkers, GE; Gualerzi, CO; Boelens, R,期刊：Journal of Biological Chemistry, 页码：10922-10932 , 文章类型： Article，,卷期：2012年287-14] Bacterial translation initiation factor IF2 promotes ribosomal subunit association, recruitment, and binding of fMet-tRNA to the ribosomal P-site and initiation dipeptide formation. Here, we present the solution structur... Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+ Leak Channels [作者：Shilling, D; Mak, DOD; Kang, DE; Foskett, JK,期刊：Journal of Biological Chemistry, 页码：10933-10944 , 文章类型： Article，,卷期：2012年287-14] Familial Alzheimer disease (FAD) is linked to mutations in the presenilin (PS) homologs. FAD mutant PS expression has several cellular consequences, including exaggerated intracellular Ca2+ ([Ca2+](i)) signaling due to e... Extreme C Terminus of Bacterial Cytoskeletal Protein FtsZ Plays Fundamental Role in Assembly Independent of Modulatory Proteins [作者：Buske, PJ; Levin, PA,期刊：Journal of Biological Chemistry, 页码：10945-10957 , 文章类型： Article，,卷期：2012年287-14] Bacterial cell division typically requires assembly of the cytoskeletal protein FtsZ into a ring (Z-ring) at the nascent division site that serves as a foundation for assembly of the division apparatus. High resolution i... Identification of Multicomponent Histidine-Aspartate Phosphorelay System Controlling Flagellar and Motility Gene Expression in Geobacter Species [作者：Ueki, T; Leang, C; Inoue, K; Lovley, DR,期刊：Journal of Biological Chemistry, 页码：10958-10966 , 文章类型： Article，,卷期：2012年287-14] Geobacter species play an important role in the natural bio-geochemical cycles of aquatic sediments and subsurface environments as well as in subsurface bioremediation by oxidizing organic compounds with the reduction of... Structure of Protein Having Inhibitory Disintegrin and Leukotriene Scavenging Functions Contained in Single Domain [作者：Xu, XQ; Francischetti, IMB; Lai, R; Ribeiro, JMC; Andersen, JF,期刊：Journal of Biological Chemistry, 页码：10967-10976 , 文章类型： Article，,卷期：2012年287-14] The antihemostatic/antiangiogenic protein tablysin-15 is a member of the CAP (cysteine-rich secretory, antigen 5, and pathogenesis-related 1 protein) superfamily and has been shown to bind the integrins alpha(IIb)beta(3)... Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-beta by Microglia [作者：Yuyama, K; Sun, H; Mitsutake, S; Igarashi, Y,期刊：Journal of Biological Chemistry, 页码：10977-10989 , 文章类型： Article，,卷期：2012年287-14] Background: Exosome is a membrane vesicle released from several types of cells, including neurons. Results: Neuronal exosomes accelerate A beta fibril formation, and the exosome-associated A beta is taken into microglia ... Allosteric Modulation of Drp1 Mechanoenzyme Assembly and Mitochondrial Fission by the Variable Domain [作者：Strack, S; Cribbs, JT,期刊：Journal of Biological Chemistry, 页码：10990-11001 , 文章类型： Article，,卷期：2012年287-14] Background: Mechanisms of Drp1-mediated mitochondrial fission are poorly understood. Results: Substitution of the Drp1 variable domain causes a spectrum of assembly and activity phenotypes but does not compromise the sta... Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation [作者：Zhou, FF; Zhang, XF; van Dam, H; ten Dijke, P; Huang, HZ; Zhang, L,期刊：Journal of Biological Chemistry, 页码：11002-11010 , 文章类型： Article，,卷期：2012年287-14] Background: The TRAF6-mediated Toll-like receptor (TLR)/IL-1 receptor (IL-1R) pathway is essential for innate immune responses and immune homeostasis. Results: USP4 deubiquitinates Lys-63-linked polyubiquitination of TRA... Uroplakins Do Not Restrict CO2 Transport through Urothelium [作者：Zocher, F; Zeidel, ML; Missner, A; Sun, TT; Zhou, G; Liao, Y; von Bodungen, M; Hill, WG; Meyers, S; Pohl, P; Mathai, JC,期刊：Journal of Biological Chemistry, 页码：11011-11017 , 文章类型： Article，,卷期：2012年287-14] Background: The tightness of various membrane barriers to CO2 is of unknown molecular origin. Results: The bladder tissue lacks carbonic anhydrase. The resulting low intra-epithelial CO2 concentration gives rise to the a... LytA, Major Autolysin of Streptococcus pneumoniae, Requires Access to Nascent Peptidoglycan [作者：Mellroth, P; Daniels, R; Eberhardt, A; Ronnlund, D; Blom, H; Widengren, J; Normark, S; Henriques-Normark, B,期刊：Journal of Biological Chemistry, 页码：11018-11029 , 文章类型： Article，,卷期：2012年287-14] Background: The regulation of cell wall hydrolysis by the pneumococcal autolysin LytA is poorly understood. Results: The cell wall is susceptible to extracellular LytA only during the stationary phase or after cell wall ... HEAT Repeat 1 Motif Is Required for B56 gamma-containing Protein Phosphatase 2A (B56 gamma-PP2A) Holoenzyme Assembly and Tumor-suppressive Function [作者：Nobumori, Y; Shouse, GP; Fan, L; Liu, X,期刊：Journal of Biological Chemistry, 页码：11030-11036 , 文章类型： Article，,卷期：2012年287-14] Background: How HEAT repeats contribute to PP2A assembly and function was unknown. Results: A tumor-associated mutation within HEAT repeat 1 disrupts PP2A function. Conclusion: HEAT repeat 1 is required for B56 gamma-PP2... Down-regulation of B Cell Receptor Signaling by Hematopoietic Progenitor Kinase 1 (HPK1)-mediated Phosphorylation and Ubiquitination of Activated B Cell Linker Protein (BLNK) [作者：Wang, XH; Li, JP; Kuo, HK; Chiu, LL; Dement, GA; Lan, JL; Chen, DY; Yang, CY; Hu, HB; Tan, TH,期刊：Journal of Biological Chemistry, 页码：11037-11048 , 文章类型： Article，,卷期：2012年287-14] Background: HPK1 is a hematopoiesis-specific Ste20-like serine/threonine kinase that suppresses immune responses and autoimmunity. Results: HPK1 knock-out B cells show loss of Thr-152 phosphorylation, 14-3-3 binding, and... 5-Hydroxytryptamine 5HT2C Receptors Form a Protein Complex with N-Methyl-D-aspartate GluN2A Subunits and Activate Phosphorylation of Src Protein to Modulate Motoneuronal Depolarization [作者：Bigford, GE; Chaudhry, NS; Keane, RW; Holohean, AM,期刊：Journal of Biological Chemistry, 页码：11049-11059 , 文章类型： Article，,卷期：2012年287-14] Background: 5-Hydroxytryptamine (5HT) modulates N-methyl-D-aspartate ( NMDA) depolarization. Results: 5HT2C co-immunoprecipitates with GluN2A and enhances NMDA motoneuronal depolarization through phosphorylation of Src(T... Exposure of Mycobacteria to Cell Wall-inhibitory Drugs Decreases Production of Arabinoglycerolipid Related to Mycolyl-arabinogalactan-peptidoglycan Metabolism [作者：Rombouts, Y; Brust, B; Ojha, AK; Maes, E; Coddeville, B; Elass-Rochard, E; Kremer, L; Guerardel, Y,期刊：Journal of Biological Chemistry, 页码：11060-11069 , 文章类型： Article，,卷期：2012年287-14] Background: Mycolyl-arabinogalactan-peptidoglycan (mAGP) represents the hallmark of the mycobacterial cell envelope and the target of several antitubercular drugs. Results: Loss of a glycolipid structurally analogous to ... Critical Role of O-Linked beta-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis [作者：Lynch, TP; Ferrer, CM; Jackson, SR; Shahriari, KS; Vosseller, K; Reginato, MJ,期刊：Journal of Biological Chemistry, 页码：11070-11081 , 文章类型： Article，,卷期：2012年287-14] Background: Cancer cells display altered metabolism and expression of the nutrient sensor O-linked beta-N-acetylglucosamine transferase (OGT). Results: Through regulation of FoxM1, OGT contributes to increased invasion, ... Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1 [作者：Parker, MW; Xu, P; Li, XB; Vander Kooi, CW,期刊：Journal of Biological Chemistry, 页码：11082-11089 , 文章类型： Article，,卷期：2012年287-14] Background: Neuropilin is an essential cell surface receptor for VEGF-A in angiogenesis. Results: VEGF-A(164) uniquely physically engages neuropilin using two distinct regions. Conclusion: These data establish the struct...