HEAT Repeat 1 Motif Is Required for B56 gamma-containing Protein Phosphatase 2A (B56 gamma-PP2A) Holoenzyme Assembly and Tumor-suppressive Function

[摘要]：Background: How HEAT repeats contribute to PP2A assembly and function was unknown. Results: A tumor-associated mutation within HEAT repeat 1 disrupts PP2A function. Conclusion: HEAT repeat 1 is required for B56 gamma-PP2A assembly and tumor-suppressive function. Significance: This work provides structural insights into HEAT repeats and illuminates a mechanism to inactivate B56 gamma-PP2A.

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