【文章名】Down-regulation of B Cell Receptor Signaling by Hematopoietic Progenitor Kinase 1 (HPK1)-mediated Phosphorylation and Ubiquitination of Activated B Cell Linker Protein (BLNK)
Down-regulation of B Cell Receptor Signaling by Hematopoietic Progenitor Kinase 1 (HPK1)-mediated Phosphorylation and Ubiquitination of Activated B Cell Linker Protein (BLNK)
[摘要]：Background: HPK1 is a hematopoiesis-specific Ste20-like serine/threonine kinase that suppresses immune responses and autoimmunity. Results: HPK1 knock-out B cells show loss of Thr-152 phosphorylation, 14-3-3 binding, and Lys-37/38/42-ubiquitination of BLNK. Conclusion: HPK1 attenuates BCR signaling via inducing phosphorylation and ubiquitination of BLNK. Significance: This is the first report of BLNK ubiquitination that is initiated by HPK1-induced phosphorylation.
