【文章名】5-Hydroxytryptamine 5HT2C Receptors Form a Protein Complex with N-Methyl-D-aspartate GluN2A Subunits and Activate Phosphorylation of Src Protein to Modulate Motoneuronal Depolarization
5-Hydroxytryptamine 5HT2C Receptors Form a Protein Complex with N-Methyl-D-aspartate GluN2A Subunits and Activate Phosphorylation of Src Protein to Modulate Motoneuronal Depolarization
作者
Bigford, GE; Chaudhry, NS; Keane, RW; Holohean, AM
[摘要]：Background: 5-Hydroxytryptamine (5HT) modulates N-methyl-D-aspartate ( NMDA) depolarization. Results: 5HT2C co-immunoprecipitates with GluN2A and enhances NMDA motoneuronal depolarization through phosphorylation of Src(Tyr-416). Conclusion: 5HT modulates NMDA through Src phosphorylation in a molecular complex that is localized in the processes of spinal neurons. Significance: 5HT2C modulation of NMDA excitation is coordinated by a molecular complex.
