The readily available and inexpensive D-tartaric acid serves as the chiral building block for synthesis of the furanoside of hygromycin A. Key to our successes in the asymmetric synthesis of the furanose segment was the ...
In the previous review paper, explorative and developmental researches of eldecalcitol (1 alpha,25-dihydroxy-2 beta-(3-hydroxypropoxy)vitamin D-3), an analog of active vitamin D-3, calcitriol (1 alpha,25-dihydroxyvitamin...
As an entry into L-like 3-deazaaristeromycins, synthesis of the enantiomer of D-like 4'-methyl-3-deazaaristeromycin is described in 11 steps from a readily accessible cyclopentenone that, in turn, is prepared from D-ribo...
2,4-Diethoxy-6-trifluoromethyl-3,4-dihydro-2H-pyran was reacted with thiols in the presence of p-toluenesulfonic acid by heating followed by treatment with trifluoroacetic acid to afford the corresponding 4-trifluoroacet...
Imidazole and imidazoline (dihydroimidazole) derivatives can serve as simple and efficient ligands for the nickel-catalyzed Kumada-Tamao-Corriu coupling reaction. Among the imidazole and imidazoline derivatives in our in...
Several simple quinoxaline derivatives were prepared by ring-opening reactions of 2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one and its N-alkyl derivatives under various reaction conditions.
The cross-metathesis of the enantioenriched homoallylic amine 8 (readily accessible by alpha-aminoallylation of decanal) with methyl vinyl ketone using the Hoveyda-Blechert catalyst 10 in presence of 10 mol% of Ti(O-i-Pr...
The click reaction is one of the latest techniques for the chemical modification of bioactive compounds. Chemical modifications of alpha-amino acid side chains are gaining significance as useful and important tools for b...
Direct asymmetric alpha-allylation of ketones with allylic alcohols is described. The combination of palladium with a new phosphine ligand bearing a chiral proline moiety promoted the reaction to afford the corresponding...
Intramolecular hydroarylation of 6-benzofuranyl alkynoates efficiently proceeded using Pd(OAc)(2) as catalyst in TFA and CH2Cl2 at room temperature. This intramolecular hydroarylation gave a mixture of regioisomers of fu...
The hypervalent iodine-induced arene cross coupling via a single-electron-transfer (SET) oxidation process could proceed in some extent even in heteroaromatic compounds, that is, several types thiophenes 1, using alkyl b...
A simple and efficient continuous flow synthesis of 2-arylbenzimidazoles from phenylenediamines and aromatic aldehydes in the presence of iodobenzene diacetate (IBD) has been developed by using a microfluidic chip reacto...
Neo-tanshinlactone (1) was synthesized by the intramolecular aryl-aryl coupling reaction of the precursor ester, which was prepared from the corresponding furan carboxylic acid (13) and naphthol (3), using a palladium re...
This review describes synthetic approaches to (+)-L-733,060 and (-)-L-733,061 reported since 1994, focusing on methods allowing the construction and control of the two stereogenic centers. The methods are divided into th...