SYNTHESIS OF 2-ARYLBENZIMIDAZOLES IN MICROFLUIDIC CHIP REACTOR

[摘要]：A simple and efficient continuous flow synthesis of 2-arylbenzimidazoles from phenylenediamines and aromatic aldehydes in the presence of iodobenzene diacetate (IBD) has been developed by using a microfluidic chip reactor system. Various substituted 2-arylbenzimidazoles were obtained in high yields within 3 min under mild conditions. Compared with the classical batch systems, the present smooth procedure is highly selective due to the enhanced thermal and mass transfer.

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