ENANTIOSELECTIVE SYNTHESIS OF CIS- AND TRANS-2-METHYL-6-NONYLPIPERIDINES: ALKALOIDS SOLENOPSIN AND ISOSOLENOPSIN

[摘要]：The cross-metathesis of the enantioenriched homoallylic amine 8 (readily accessible by alpha-aminoallylation of decanal) with methyl vinyl ketone using the Hoveyda-Blechert catalyst 10 in presence of 10 mol% of Ti(O-i-Pr)(4) led exclusively to the (E)-enone 11, which by stereoselective reductive amination affords (+)-isosolenopsin (3a) and (+)-solenopsin (4a) with excellent selectivities.

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