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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共400948条记录   A novel ascomycetous endophytic association in the rhizoids of the leafy liverwort family Schistochilaceae (Jungermanniidae, Hepaticopsida) [作者：Pressel, S; Ligrone, R; Duckett, JG; Davis, EC,期刊：American Journal of Botany, 页码：531-541 , 文章类型： Article，,卷期：2008年95-5] Liverworts form diverse associations with endophytic fungi similar to mycorrhizas in vascular plants. Whereas the widespread occurrence of glomeromycotes in the basal liverwort lineages is well documented, knowledge of t... Bryophyte diaspore bank: A genetic memory? Genetic structure and genetic diversity of surface populations and diaspore bank in the liverwort Mannia fragrans (Aytoniaceae) [作者：Hock, Z; Szovenyi, P; Schneller, JJ; Toth, Z; Urmi, E,期刊：American Journal of Botany, 页码：542-548 , 文章类型： Article，,卷期：2008年95-5] Propagule banks are assumed to be able to store considerable genetic variability. Bryophyte populations are expected to rely more heavily on stored propagules than those of seed plants due to the vulnerability of the hap... Relevance of multidrug resistance in the age of targeted therapy [作者：Turk, D; Szakacs, G,期刊：Current Opinion in Drug Discovery & Development, 页码：246-252 , 文章类型： Review，,卷期：2009年12-2] Targeted drugs inhibit specific pathways that contribute to the malignant phenotype of cancer cells. The initial success of molecularly targeted therapies raised hope that newly developed agents would evade the general m... Targeting TGF beta-mediated processes in cancer [作者：Romano, MF,期刊：Current Opinion in Drug Discovery & Development, 页码：253-263 , 文章类型： Review，,卷期：2009年12-2] TGF beta is a pleiotropic cytokine that has regulatory roles during embryonic development and adult tissue homeostasis, and is especially important for epithelial, neural and immune system differentiation and function. A... Novel approaches on epigenetics [作者：Papait, R; Monti, E; Bonapace, IM,期刊：Current Opinion in Drug Discovery & Development, 页码：264-275 , 文章类型： Review，,卷期：2009年12-2] Epigenetic changes occurring during the development of organisms can be altered by the presence of synthetic substances in the environment, resulting in developmental reprogramming and disease. The occurrence of such cha... Bispecific antibodies for cancer therapy [作者：Chames, P; Baty, D,期刊：Current Opinion in Drug Discovery & Development, 页码：276-283 , 文章类型： Review，,卷期：2009年12-2] In recent decades, mAbs have emerged as therapeutics. Nine mAbs have been approved for cancer therapy. However, the efficiency of mAbs is far from optimal, and antibody engineering is actively used to improve the molecul... Pyrazoline-based mycobactin analogues as MAO-inhibitors [作者：Jayaprakash, V; Sinha, BN; Ucar, G; Ercan, A,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6362-6368 , 文章类型： Article，,卷期：2008年18-24] 3,5-Diaryl carbothioamide pyrazolines designed as mycobactin analogs (mycobacterial siderophore) were reported to be potent antitubercular agents under iron limiting condition in our earlier study. Clinical complications... The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing [作者：Jones, CD; Andrews, DM; Barker, AJ; Blades, K; Daunt, P; East, S; Geh, C; Graham, MA; Johnson, KM; Loddick, SA; McFarland, HM; McGregor, A; Moss, L; Rudge, DA; Simpson, PB; Swain, ML; Tam, KY; Tucker, JA; Walker, M,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6963-6967 , 文章类型： Article，,卷期：2008年18-24] The development of a novel series of imidazole pyrimidine amides as cyclin-dependent kinase (CDK) inhibitors is described. Optimisation of inhibitory potency against multiple CDK's (1, 2 and 9) resulted in imidazole pyri... alpha-S-GalCer: Synthesis and evaluation for iNKT cell stimulation [作者：Blauvelt, ML; Khalili, M; Jaung, W; Paulsen, J; Anderson, AC; Wilson, SB; Howell, AR,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6968-6970 , 文章类型： Article，,卷期：2008年18-24] The synthesis and evaluation for iNKT stimulation of alpha-S-galactosylceramide is reported. Prepared by alkylation of a galactosylthiol, this analog of the potent immunostimulatory agent, KRN7000, did not stimulate iNKT... Triterpene based compounds with potent anti-maturation activity against HIV-1 [作者：Gerrish, D; Kim, IC; Kumar, DV; Austin, H; Garrus, JE; Baichwal, V; Saunders, M; McKinnon, RS; Anderson, MB; Carlson, R; Arranz-Plaza, E; Yager, KM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6971-6380 , 文章类型： Article，,卷期：2008年18-24] Efforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency, physicochemical properties, and enhanced oral absorption in rats.... Local DNA Topography Correlates with Functional Noncoding Regions of the Human Genome [作者：Parker, SCJ; Hansen, L; Abaan, HO; Tullius, TD; Margulies, EH,期刊：Science, 页码：389-392 , 文章类型： Article，,卷期：2009年324-5925] The three-dimensional molecular structure of DNA, specifically the shape of the backbone and grooves of genomic DNA, can be dramatically affected by nucleotide changes, which can cause differences in protein-binding affi... In Vivo Analysis of Dendritic Cell Development and Homeostasis [作者：Liu, K; Victora, GD; Schwickert, TA; Guermonprez, P; Meredith, MM; Yao, KH; Chu, FF; Randolph, GJ; Rudensky, AY; Nussenzweig, M,期刊：Science, 页码：392-397 , 文章类型： Article，,卷期：2009年324-5925] Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates fro... A Contemporary Microbially Maintained Subglacial Ferrous "Ocean" [作者：Mikucki, JA; Pearson, A; Johnston, DT; Turchyn, AV; Farquhar, J; Schrag, DP; Anbar, AD; Priscu, JC; Lee, PA,期刊：Science, 页码：397-400 , 文章类型： Article，,卷期：2009年324-5925] An active microbial assemblage cycles sulfur in a sulfate-rich, ancient marine brine beneath Taylor Glacier, an outlet glacier of the East Antarctic Ice Sheet, with Fe(III) serving as the terminal electron acceptor. Isot... Dihydropyrazolopyrimidine Inhibitors of K(V)1.5 (I-Kur) [作者：Vaccaro, W; Huynh, T; Lloyd, J; Atwal, K; Finlay, HJ; Levesque, P; Conder, ML; Jenkins-West, T; Shi, H; Sun, L,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6381-6385 , 文章类型： Article，,卷期：2008年18-24] A series of dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I-Kur) have been identified. The synthesis, structure-activity relationships and selectivity against several other ion channels are described. (C) 2008 Elsevie... Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity [作者：Cui, YM; Yasutomi, E; Otani, Y; Yoshinaga, T; Ido, K; Sawada, K; Kawahata, M; Yamaguchi, K; Ohwada, T,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6386-6389 , 文章类型： Article，,卷期：2008年18-24] Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBK ... Benzimidazole- and benzoxazole-based inhibitors of Rho kinase [作者：Sessions, EH; Yin, Y; Bannister, TD; Weiser, A; Griffin, E; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Schurer, SC; Schroter, T; LoGrasso, P; Feng, YB,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：6390-6393 , 文章类型： Article，,卷期：2008年18-24] Inhibitors of Rho kinase have been developed based on two distinct scaffolds, benzimidazoles, and benzoxazoles. SAR studies and efforts to optimize the initial lead compounds are described. Novel selective inhibitors of ...