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Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity

作者	Cui, YM; Yasutomi, E; Otani, Y; Yoshinaga, T; Ido, K; Sawada, K; Kawahata, M; Yamaguchi, K; Ohwada, T

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2008年18-24; 页码 6386-6389

关联知识点

[摘要]：Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBK alpha channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity. (C) 2008 Elsevier Ltd. All rights reserved.
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