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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共85条记录   Antitubercular activity of alpha,omega-diaminoalkanes, H2N(CH2)(n)NH2 [作者：Vergara, FMF; Henriques, MDMO; Candea, ALP; Wardell, JL; De Souza, MVN,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4937-4938 , 文章类型： Article，,卷期：2009年19-17] A series of 11 alpha,omega-diaminoalkanes, (H2N(CH2)nNH(2), n = 2-12) have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Compounds, (H2N(CH2)(n)NH2, n = 9-12), exhibit... Unsaturated genistein disaccharide glycoside as a novel agent affecting microtubules [作者：Rusin, A; Gogler, A; Glowala-Kosinska, M; Bochenek, D; Gruca, A; Grynkiewicz, G; Zawisza, J; Szeja, W; Krawczyk, Z,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4939-4943 , 文章类型： Article，,卷期：2009年19-17] Genistein, due to its recognized chemopreventive and antitumor potential, is a molecule of interest as a lead compound in drug design. While multiple molecular targets for genistein have been identified, so far neither f... Formation of spiroiminodihydantoin nucleoside from 8-oxo-7,8-dihydro-2 '-deoxyguanosine by nitric oxide under aerobic conditions [作者：Suzuki, T,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4944-4947 , 文章类型： Article，,卷期：2009年19-17] When 8-oxo-7,8-dihydro-2'-deoxyguanosine in potassium phosphate buffer of pH 7.4 was bubbled by nitric oxide at room temperature under aerobic conditions, two major products were formed. They were identified as the diast... The synthesis of 2-and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity [作者：Leboho, TC; Michael, JP; van Otterlo, WAL; van Vuuren, SF; de Koning, CB,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4948-4951 , 文章类型： Article，,卷期：2009年19-17] A series of 2- and 3-aryl substituted indoles and two 1,3,4,5-tetrahydropyrano[4,3-b] indoles were synthesized from indole and 5-methoxyindole. The 2- aryl indoles were synthesized from the 1-(phenylsulfonyl) indole deri... Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors [作者：Gonzalez, A; Quirante, J; Nieto, J; Almeida, MR; Saraiva, MJ; Planas, A; Arsequell, G; Valencia, G,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：5270-5273 , 文章类型： Article，,卷期：2009年19-17] The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) brillogenesis inhibitor design. Among the series of isatin analogues prepared and tested, the nitro compound 1,3-dihydro3-[(4-nit... A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta [作者：Reinke, AA; Seh, HY; Gestwicki, JE,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4952-4957 , 文章类型： Article，,卷期：2009年19-17] Aggregated amyloid-beta (A beta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibri... Schisanwilsonins A-G and related anti-HBV lignans from the fruits of Schisandra wilsoniana [作者：Ma, WH; Lu, Y; Huang, H; Zhou, P; Chen, DF,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4958-4962 , 文章类型： Article，,卷期：2009年19-17] Seven new dibenzocyclooctane lignans, schisanwilsonins A-G (1-7), were isolated from the fruits of Schisandra wilsoniana, together with five known lignans (8-12). The structures of these new compounds were elucidated by ... Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH) [作者：Kummerle, AE; Vieira, MM; Schmitt, M; Miranda, ALP; Fraga, CAM; Bourguignon, JJ; Barreiro, EJ,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4963-4966 , 文章类型： Article，,卷期：2009年19-17] A set of six azaheterocycles were designed as conformationnaly-constrained N-acylhydrazones and tested as analgesics. (C) 2009 Elsevier Ltd. All rights reserved. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4) [作者：Williams, R; Johnson, KA; Gentry, PR; Niswender, CM; Weaver, CD; Conn, PJ; Lindsley, CW; Hopkins, CR,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4967-4970 , 文章类型： Article，,卷期：2009年19-17] This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an i... Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Bronsted bases in N -> N proton transfer [作者：Donahue, MG; Hong, KB; Johnston, JN,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4971-4973 , 文章类型： Article，,卷期：2009年19-17] Bronsted acid-induced fragmentation of a triazoline is used as a tool to identify Bronsted base additives capable of playing the role of a proton shuttle. Relative to water, dimethyl formamide accelerates proton transfer... Triple recognition of B-DNA [作者：Willis, B; Arya, DP,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4974-4979 , 文章类型： Article，,卷期：2009年19-17] A novel conjugate of Hoechst 33258, pyrene and neomycin was synthesized and examined for its binding and stabilization of A-T rich DNA duplexes using spectroscopic and viscometric techniques. The conjugate, containing th... 2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer [作者：Chen, ZC; Venkatesan, AM; Dehnhardt, CM; Dos Santos, O; Delos Santos, E; Ayral-Kaloustian, S; Chen, L; Geng, Y; Arndt, KT; Lucas, J; Chaudhary, I; Mansour, TS,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4980-4983 , 文章类型： Article，,卷期：2009年19-17] The synthesis and SAR of a series of 2,4-diamino-quinazoline derivatives as beta-catenin/Tcf-4 inhibitors are described. This series was developed by modifying the initial lead 1, which was identified by screening of our... Development of a novel expression, ZI(MAX)/K-ZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts [作者：Ingalsbe, ML; St Denis, JD; McGahan, ME; Steiner, WW; Priefer, R,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4984-4987 , 文章类型： Article，,卷期：2009年19-17] Due to the increasing number of strains of drug-resistant bacteria, the development of new antibiotics has become increasingly important. The antibacterial properties of quaternary amines and their derivatives on both Gr... 4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents [作者：Duan, MS; Aquino, C; Dorsey, GF; Ferris, R; Kazmierski, WM,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4988-4992 , 文章类型： Article，,卷期：2009年19-17] A series of 4,4-disubstituted cyclohexylamine based CCR5 antagonists has been designed and synthesized. Their antiviral structure-activity relationship has been extensively explored. (C) 2009 Elsevier Ltd. All rights res... A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason [作者：Hills, ID; Holloway, MK; de Leon, P; Nomland, A; Zhu, H; Rajapakse, H; Allison, TJ; Munshi, SK; Colussi, D; Pietrak, BL; Toolan, D; Haugabook, SJ; Graham, SL; Stachel, SJ,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4993-4995 , 文章类型： Article，,卷期：2009年19-17] During our ongoing efforts to develop a small molecule inhibitor targeting the beta-amyloid cleaving enzyme (BACE-1), we discovered a class of compounds bearing an aminoimidazole motif. Initial optimization led to potent... Site-specific incorporation of PEGylated amino acids into proteins using nonnatural amino acid mutagenesis [作者：Shozen, N; Iijima, I; Hohsaka, T,期刊：Bioorganic & Medicinal Chemistry Letters, 页码：4909-4911 , 文章类型： Article，,卷期：2009年19-17] Site-directed incorporation of PEGylated nonnatural amino acids with 4, 8, and 12 repeated ethylene glycol units was examined in a cell-free translation system. PEGylated aminophenylalanine derivatives were successfully ...