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[摘要]：Seven new dibenzocyclooctane lignans, schisanwilsonins A-G (1-7), were isolated from the fruits of Schisandra wilsoniana, together with five known lignans (8-12). The structures of these new compounds were elucidated by spectroscopic methods including 2D-NMR techniques. The 12 lignans were tested for antihepatitis B virus (HBV) activity in vitro. Schisanwilsonin D ( 4), schisantherin C (9), deoxyschizandrin (10) and (+)-gomisin K-3 (11) showed anti-HBV activity. 9 exhibited the most potent anti-HBV activity with potency against HBsAg and HBeAg secretion by 59.7% and 34.7%, respectively, at 50 mu g/mL. (C) 2009 Elsevier Ltd. All rights reserved. |
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