- A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery
[作者：Okada, C; Yamashita, E; Lee, SJ; Shibata, S; Katahira, J; Nakagawa, A; Yoneda, Y; Tsukihara, T,期刊：Science, 页码：1275-1279 , 文章类型： Article，,卷期：2009年326-5957]
- Nuclear export of microRNAs (miRNAs) by exportin-5 (Exp-5) is an essential step in miRNA biogenesis. Here, we present the 2.9 angstrom structure of the pre-miRNA nuclear export machinery formed by pre-miRNA complexed wit...
- Proteome Organization in a Genome-Reduced Bacterium
[作者：Kuhner, S; van Noort, V; Betts, MJ; Leo-Macias, A; Batisse, C; Rode, M; Yamada, T; Maier, T; Bader, S; Beltran-Alvarez, P; Castano-Diez, D; Chen, WH; Devos, D; Guell, M; Norambuena, T; Racke, I; Rybin, V; Schmidt, A; Yus, E; Aebersold, R; Herrmann, R; Bot,期刊：Science, 页码：1235-1240 , 文章类型： Article，,卷期：2009年326-5957]
- The genome of Mycoplasma pneumoniae is among the smallest found in self-replicating organisms. To study the basic principles of bacterial proteome organization, we used tandem affinity purification-mass spectrometry (TAP...
- Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus
[作者：Tawar, RG; Duquerroy, S; Vonrhein, C; Varela, PF; Damier-Piolle, L; Castagne, N; MacLellan, K; Bedouelle, H; Bricogne, G; Bhella, D; Eleouet, JF; Rey, FA,期刊：Science, 页码：1279-1283 , 文章类型： Article，,卷期：2009年326-5957]
- The respiratory syncytial virus (RSV) is an important human pathogen, yet neither a vaccine nor effective therapies are available to treat infection. To help elucidate the replication mechanism of this RNA virus, we dete...
- Directed Transport of Atoms in a Hamiltonian Quantum Ratchet
[作者：Salger, T; Kling, S; Hecking, T; Geckeler, C; Morales-Molina, L; Weitz, M,期刊：Science, 页码：1241-1243 , 文章类型： Article，,卷期：2009年326-5957]
- Classical ratchet potentials, which alternate a driving potential with periodic random dissipative motion, can account for the operation of biological motors. We demonstrate the operation of a quantum ratchet, which diff...
- Crystal Structure of the Catalytic Core of an RNA-Polymerase Ribozyme
[作者：Shechner, DM; Grant, RA; Bagby, SC; Koldobskaya, Y; Piccirilli, JA; Bartel, DP,期刊：Science, 页码：1271-1275 , 文章类型： Article，,卷期：2009年326-5957]
- Primordial organisms of the putative RNA world would have required polymerase ribozymes able to replicate RNA. Known ribozymes with polymerase activity best approximating that needed for RNA replication contain at their ...
- Transcriptome Complexity in a Genome-Reduced Bacterium
[作者：Guell, M; van Noort, V; Yus, E; Chen, WH; Leigh-Bell, J; Michalodimitrakis, K; Yamada, T; Arumugam, M; Doerks, T; Kuhner, S; Rode, M; Suyama, M; Schmidt, S; Gavin, AC; Bork, P; Serrano, L,期刊：Science, 页码：1268-1271 , 文章类型： Article，,卷期：2009年326-5957]
- To study basic principles of transcriptome organization in bacteria, we analyzed one of the smallest self-replicating organisms, Mycoplasma pneumoniae. We combined strand-specific tiling arrays, complemented by transcrip...
- Impact of Genome Reduction on Bacterial Metabolism and Its Regulation
[作者：Yus, E; Maier, T; Michalodimitrakis, K; van Noort, V; Yamada, T; Chen, WH; Wodke, JAH; Guell, M; Martinez, S; Bourgeois, R; Kuhner, S; Raineri, E; Letunic, I; Kalinina, OV; Rode, M; Herrmann, R; Gutierrez-Gallego, R; Russell, RB; Gavin, AC; Bork, P; Serra,期刊：Science, 页码：1263-1268 , 文章类型： Article，,卷期：2009年326-5957]
- To understand basic principles of bacterial metabolism organization and regulation, but also the impact of genome size, we systematically studied one of the smallest bacteria, Mycoplasma pneumoniae. A manually curated me...
- Extensive, Recent Intron Gains in Daphnia Populations
[作者：Li, WL; Tucker, AE; Sung, W; Thomas, WK; Lynch, M,期刊：Science, 页码：1260-1262 , 文章类型： Article，,卷期：2009年326-5957]
- Rates and mechanisms of intron gain and loss have traditionally been inferred from alignments of highly conserved genes sampled from phylogenetically distant taxa. We report a population-genomic approach that detected 24...
- Global Signatures and Dynamical Origins of the Little Ice Age and Medieval Climate Anomaly
[作者：Mann, ME; Zhang, ZH; Rutherford, S; Bradley, RS; Hughes, MK; Shindell, D; Ammann, C; Faluvegi, G; Ni, FB,期刊：Science, 页码：1256-1260 , 文章类型： Article，,卷期：2009年326-5957]
- Global temperatures are known to have varied over the past 1500 years, but the spatial patterns have remained poorly defined. We used a global climate proxy network to reconstruct surface temperature patterns over this i...
- Selective Phenol Hydrogenation to Cyclohexanone Over a Dual Supported Pd-Lewis Acid Catalyst
[作者：Liu, HZ; Jiang, T; Han, BX; Liang, SG; Zhou, YX,期刊：Science, 页码：1250-1252 , 文章类型： Article，,卷期：2009年326-5957]
- Cyclohexanone is an industrially important intermediate in the synthesis of materials such as nylon, but preparing it efficiently through direct hydrogenation of phenol is hindered by over-reduction to cyclohexanol. Here...
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