- Efficient Access to a Versatile 5,6-Dithio-1,10-phenanthroline Building Block and Corresponding Organometallic Complexes.
[作者:Chesneau, Bertrand;Passelande, Angelique;Hudhomme, Pietrick;,期刊:Organic Letters, 页码:649-652 , 文章类型: 研究论文,,卷期:2009年11-3]
- A facile access to 5,6-bis(2-cyanoethylsulfanyl)-1,10-phenanthroline (1) and its ruthenium(II) bipyridine complex (2), as versatile building blocks for the straightforward synthesis of 5,6-dithio functionalized 1,10-phen...
- Total Synthesis of FR901483.
[作者:Carson, Cheryl A.;Kerr, Michael A.;,期刊:Organic Letters, 页码:777-779 , 文章类型: 研究论文,,卷期:2009年11-3]
- The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 (I) was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor-acceptor cyclopro...
- Use of 4-Cyanocoumarins as Dienophiles in a Facile Synthesis of Highly Substituted Dibenzopyranones.
[作者:Jung, Michael E.;Allen, Damian A.;,期刊:Organic Letters, 页码:757-760 , 文章类型: 研究论文,,卷期:2009年11-3]
- A new synthesis of dibenzopyranones, e.g., I (R1 = H, Me, MeO; R2 = H, Me, Cl), is reported via the Diels-Alder cycloaddn. of 4-cyanocoumarins with 1-silyloxydienes to give the corresponding adducts which were then conve...
- Stereodivergency of Triazolium and Imidazolium-Derived NHCs for Catalytic, Enantioselective Cyclopentane Synthesis.
[作者:Kaeobamrung, Juthanat;Bode, Jeffrey W.;,期刊:Organic Letters, 页码:677-680 , 文章类型: 研究论文,,卷期:2009年11-3]
- Chiral triazolium- and imidazolium-derived N-heterocyclic carbene catalysts promote the direct annulation of a,b-unsatd. aldehydes R1CH:CHCHO (R1 = Ph, 4-MeOC6H4, 1-naphthyl, 2-furyl, etc.) and achiral a-hydroxy enones R...
- An Efficient Method for Construction of the Angularly Fused 6,3,5-Tricyclic Skeleton of Mycorrhizin A and Its Analogues.
[作者:Yu, Binxun;Jiang, Tuo;Quan, Weiguo;Li, Junpeng;Pan, Xinfu;She, Xuegong;,期刊:Organic Letters, 页码:629-632 , 文章类型: 研究论文,,卷期:2009年11-3]
- The angularly fused 6,3,5-tricyclic system is readily generated via a cascade cyclization under acid promotion. The reaction proceeds at room temp. with high stereochem. fidelity from the electrophilic center of the epo...
- Enantioselective Total Synthesis of Aspergillide C.
[作者:Nagasawa, Tomohiro;Kuwahara, Shigefumi;,期刊:Organic Letters, 页码:761-764 , 文章类型: 研究论文,,卷期:2009年11-3]
- The first enantioselective total synthesis of aspergillide C (I), a cytotoxic 14-membered macrolide isolated from the marine-derived fungus Aspergillus ostianus, has been accomplished from a com. available chiral glycido...
- Stereocontrolled Approach to Bromofluoroalkenes and Their Use for the Synthesis of Tri- and Tetrasubstituted Fluoroalkenes.
[作者:Landelle, Gregory;Champagne, Pier Alexandre;Barbeau, Xavier;Paquin, Jean-Francois;,期刊:Organic Letters, 页码:681-684 , 文章类型: 研究论文,,卷期:2009年11-3]
- An addn./elimination reaction of organolithium reagents to silylated b,b-difluorostyrene derivs., e.g. I (R = Me3Si, Et3Si, R1 = H, 3-Cl), followed by a bromination/desilicobromination reaction provides a simple and effe...
- Polyisobutylene-Anchored N-Heterocyclic Carbene Ligands.
[作者:Hongfa, Chayanant;Su, Haw-Lih;Bazzi, Hassan S.;Bergbreiter, David E.;,期刊:Organic Letters, 页码:665-667 , 文章类型: 研究论文,,卷期:2009年11-3]
- The synthesis of polyisobutylene (PIB)-supported N-heterocyclic carbenes (NHCs) that are useful as ligands for recoverable/recyclable organometallic complexes is described. Both PIB-bound carbenes analogous to SIMes and...
- Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.
[作者:Oh, Dong-Chan;Scott, Jarrod J.;Currie, Cameron R.;Clardy, Jon;,期刊:Organic Letters, 页码:633-636 , 文章类型: 研究论文,,卷期:2009年11-3]
- A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a polyene peroxide, mycangimycin (I), with pronounced antifungal activity. Its structure, abs. configuration, and biol. activity wer...
- Total synthesis of (+)-azinothricin and (+)-kettapeptin.
[作者:Hale, Karl J.;Manaviazar, Soraya;George, Jonathan H.;Walters, Marcus A.;Dalby, Stephen M.;,期刊:Organic Letters, 页码:733-736 , 文章类型: 研究论文,,卷期:2009年11-3]
- Asym. total syntheses of (+)-azinothricin (I, R = Et) and (+)-kettapeptin (I, R = Me) were achieved. The synthetic pathway exploits a highly chemoselective coupling reaction between the fully elaborated cyclodepsipeptid...
- Synthesis of A83586C analogs with potent anticancer and b-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb.
[作者:Hale, Karl J.;Manaviazar, Soraya;Lazarides, Linos;George, Jonathan;Walters, Marcus A.;Cai, Jiaqiang;Delisser, Vern M.;Bhatia, Gurpreet S.;Peak, S. Andrew;Dalby, Stephen M.;Lefranc, Amandine;Chen, Ying-Nan P.;Wood, Alexander W.;Crowe, Paul;Erwin, Pauline;E,期刊:Organic Letters, 页码:737-740 , 文章类型: 研究论文,,卷期:2009年11-3]
- The synthesis of three potent new antitumor agents is described: the A83586C-citropeptin hybrid (I, R = OMe), the A83586C-GE3 hybrid (I, R = H), and L-Pro-A83586C (II). Significantly, compds. I (R = OMe, H) function as ...
- Design, synthesis, and application of enantioselective coupling reagent with a traceless chiral auxiliary.
[作者:Kolesinska, Beata;Kaminski, Zbigniew J.;,期刊:Organic Letters, 页码:765-768 , 文章类型: 研究论文,,卷期:2009年11-3]
- Stable chiral N-triazinylbrucinium tetrafluoroborate enantioselectively activates racemic carboxylic acids yielding enantiomerically enriched amides, esters, and dipeptides with er from 8:92 to 0.5:99.5. Due to the depa...
- A New Strategy for the Synthesis of Optically Pure b-Fluoroalkyl b-Amino Acid Derivatives.
[作者:Fustero, Santos;del Pozo, Carlos;Catalan, Silvia;Aleman, Jose;Parra, Alejandro;Marcos, Vanesa;Ruano, Jose Luis Garcia;,期刊:Organic Letters, 页码:641-644 , 文章类型: 研究论文,,卷期:2009年11-3]
- The first general approach for the diastereoselective formation of a variety of optically pure anti-b-fluoroalkyl b-amino acid derivs. is described. The process relies on the stereocontrolled reaction, mediated by a rem...
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