- Nanoclusters of GPI-Anchored Proteins Are Formed by Cortical Actin-Driven Activity
[作者：Goswami, D; Gowrishankar, K; Bilgrami, S; Ghosh, S; Raghupathy, R; Chadda, R; Vishwakarma, R; Rao, M; Mayor, S,期刊：Cell, 页码：1085-1097 , 文章类型： Article，,卷期：2008年135-6]
- Several cell-surface lipid-tethered proteins exhibit a concentration-independent, cholesterol-sensitive organization of nanoscale clusters and monomers. To understand the mechanism of formation of these clusters, we inve...
- Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
[作者：Lovell, JF; Billen, LP; Bindner, S; Shamas-Din, A; Fradin, C; Leber, B; Andrews, DW,期刊：Cell, 页码：1074-1084 , 文章类型： Article，,卷期：2008年135-6]
- In normal circumstances, the Bcl-2 family dutifully governs when cells die. However, the rules of engagement between the pro- and antiapoptotic family members are still contested, and how Bax is transformed from a cytoso...
- Transepithelial Projections from Basal Cells Are Luminal Sensors in Pseudostratified Epithelia
[作者：Shum, WWC; Da Silva, N; Mckee, M; Smith, PJS; Brown, D; Breton, S,期刊：Cell, 页码：1108-1117 , 文章类型： Article，,卷期：2008年135-6]
- Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long ...
- Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets
[作者：Shubeita, GT; Tran, SL; Xu, J; Vershinin, M; Cermelli, S; Cotton, SL; Welte, MA; Gross, SP,期刊：Cell, 页码：1098-1107 , 文章类型： Article，,卷期：2008年135-6]
- The microtubule motor kinesin-1 plays central roles in intracellular transport. It has been widely assumed that many cellular cargos are moved by multiple kinesins and that cargos with more motors move faster and for lon...
- Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
[作者：Wilson, A; Laurenti, E; Oser, G; van der Wath, RC; Blanco-Bose, W; Jaworski, M; Offner, S; Dunant, CF; Eshkind, L; Bockamp, E; Lio, P; MacDonald, HR; Trumpp, A,期刊：Cell, 页码：1118-1129 , 文章类型： Article，,卷期：2008年135-6]
- Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting...
- AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations
[作者：Robbiani, DF; Bothmer, A; Callen, E; Reina-San-Martin, B; Dorsett, Y; Difilippantonio, S; Bolland, DJ; Chen, HT; Corcoran, AE; Nussenzweig, A; Nussenzweig, MC,期刊：Cell, 页码：1028-1038 , 文章类型： Article，,卷期：2008年135-6]
- Chromosomal translocation requires formation of paired double-strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heav...
- CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore
[作者：Hori, T; Amano, M; Suzuki, A; Backer, CB; Welburn, JP; Dong, YM; McEwen, BF; Shang, WH; Suzuki, E; Okawa, K; Cheeseman, IM; Fukagawa, T,期刊：Cell, 页码：1039-1052 , 文章类型： Article，,卷期：2008年135-6]
- Kinetochore specification and assembly requires the targeted deposition of specialized nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A is not sufficient to drive full-kinetochore asse...
- Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death
[作者：Zhang, XQ; Chen, SH; Yoo, S; Chakrabarti, S; Zhang, T; Ke, T; Oberti, C; Yong, SL; Fang, F; Li, L; de la Fuente, R; Wang, LJ; Chen, QY; Wang, QK,期刊：Cell, 页码：1017-1027 , 文章类型： Article，,卷期：2008年135-6]
- Atrial fibrillation (AF) is the most common form of sustained clinical arrhythmia. We previously mapped an AF locus to chromosome 5p13 in an AF family with sudden death in early childhood. Here we show that the specific ...
- Incompatibility of Nuclear and Mitochondrial Genomes Causes Hybrid Sterility between Two Yeast Species
[作者：Lee, HY; Chou, JY; Cheong, L; Chang, NH; Yang, SY; Leu, JY,期刊：Cell, 页码：1065-1073 , 文章类型： Article，,卷期：2008年135-6]
- Hybrids between species are usually unviable or sterile. One possible mechanism causing reproductive isolation is incompatibility between genes from different species. These "speciation'' genes are interacting components...
- Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors
[作者：De Val, S; Chi, NC; Meadows, SM; Minovitsky, S; Anderson, JP; Harris, IS; Ehlers, ML; Agarwal, P; Visel, A; Xu, SM; Pennacchio, LA; Dubchak, I; Krieg, PA; Stainier, DYR; Black, BL,期刊：Cell, 页码：1053-1064 , 文章类型： Article，,卷期：2008年135-6]
- Vascular development begins when mesodermal cells differentiate into endothelial cells, which then form primitive vessels. It has been hypothesized that endothelial-specific gene expression may be regulated combinatorial...
- Green Fluorescent Protein Glows Gold
[作者：Miyawaki, A,期刊：Cell, 页码：987-990 , 文章类型： Editorial Material，,卷期：2008年135-6]
- The awarding of this year's Nobel Prize in Chemistry to Osamu Shimomura, Martin Chalfie, and Roger Tsien for their discovery and development of green fluorescent protein earns this humble jellyfish protein a place of hon...
- Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity
[作者：Tsai, AG; Lu, HH; Raghavan, SC; Muschen, M; Hsieh, CL; Lieber, MR,期刊：Cell, 页码：1130-1142 , 文章类型： Article，,卷期：2008年135-6]
- We have assembled, annotated, and analyzed a database of over 1700 breakpoints from the most common chromosomal rearrangements in human leukemias and lymphomas. Using this database, we show that although the CpG dinucleo...
- On Viruses, Discovery, and Recognition
[作者：Weiss, RA,期刊：Cell, 页码：983-986 , 文章类型： Editorial Material，,卷期：2008年135-6]
- This year's Nobel Prize in Physiology or Medicine rewards the discoverers of two viruses that cause major afflictions of humankind. Identifying human papilloma virus (HPV) and human immunodeficiency virus (HIV) might now...
- Counting Motors by Force
[作者：St Johnston, D,期刊：Cell, 页码：1000-1001 , 文章类型： Editorial Material，,卷期：2008年135-6]
- Properties of the microtubule motor protein kinesin-1 have been well characterized in vitro but not in the viscous environment of a cell. By measuring the force that kinesin-1 exerts on lipid droplets in fly embryos, Shu...
- Clash of the Genomes
[作者：Barbash, DA,期刊：Cell, 页码：1002-1003 , 文章类型： Editorial Material，,卷期：2008年135-6]
- Full-genome sequences of multiple yeast species offer exciting possibilities for the functional analysis of yeast evolution and speciation. Lee et al. ( 2008) now report that hybrid sterility between two yeast species is...
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