Bcl-2 Proteins and Apoptosis: Choose Your Partner

[摘要]：

The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. ( 2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.

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