- 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1
[作者:Berdichevsky, A; Nedelcu, S; Boulias, K; Bishop, NA; Guarente, L; Horvitz, HR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18927-18932 , 文章类型: Article,,卷期:2010年107-44]
- Studies of long-lived Caenorhabditis elegans mutants have identified several genes that function to limit lifespan, i.e., loss-of-function mutations in these genes promote longevity. By contrast, little is known about ge...
- Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
[作者:Benson, AK; Kelly, SA; Legge, R; Ma, FR; Low, SJ; Kim, J; Zhang, M; Oh, PL; Nehrenberg, D; Hua, KJ; Kachman, SD; Moriyama, EN; Walter, J; Peterson, DA; Pomp, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18933-18938 , 文章类型: Article,,卷期:2010年107-44]
- In vertebrates, including humans, individuals harbor gut microbial communities whose species composition and relative proportions of dominant microbial groups are tremendously varied. Although external and stochastic fac...
- T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell
[作者:Serwold, T; Hochedlinger, K; Swindle, J; Hedgpeth, J; Jaenisch, R; Weissman, IL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18939-18943 , 文章类型: Article,,卷期:2010年107-44]
- The conversion of mature somatic cells into pluripotent stem cells, both by nuclear transfer and transduction with specific "reprogramming" genes, represents a major advance in regenerative medicine. Pluripotent stem cel...
- SHEP1 partners with CasL to promote marginal zone B-cell maturation
[作者:Browne, CD; Hoefer, MM; Chintalapati, SK; Cato, MH; Wallez, Y; Ostertag, DV; Pasquale, EB; Rickert, RC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18944-18949 , 文章类型: Article,,卷期:2010年107-44]
- The marginal zone is a cellular niche bordering the marginal sinus of the spleen that contains specialized B-cell and macrophage subsets poised to capture bloodborne antigens. Marginal zone B cells are retained in this n...
- Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354
[作者:Kaufmann, B; Vogt, MR; Goudsmit, J; Holdaway, HA; Aksyuk, AA; Chipman, PR; Kuhn, RJ; Diamond, MS; Rossmann, MG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18950-18955 , 文章类型: Article,,卷期:2010年107-44]
- Many flaviviruses are significant human pathogens, with the humoral immune response playing an essential role in restricting infection and disease. CR4354, a human monoclonal antibody isolated from a patient, neutralizes...
- Soluble plasma HLA peptidome as a potential source for cancer biomarkers
[作者:Bassani-Sternberg, M; Barnea, E; Beer, I; Avivi, I; Katz, T; Admon, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18769-18776 , 文章类型: Article,,卷期:2010年107-44]
- The HLA molecules are membrane-bound transporters that carry peptides from the cytoplasm to the cell surface for surveillance by circulating T lymphocytes. Although low levels of soluble HLA molecules (sHLA) are normally...
- Monitoring ion-channel function in real time through quantum decoherence
[作者:Hall, LT; Hill, CD; Cole, JH; Stadler, B; Caruso, F; Mulvaney, P; Wrachtrup, J; Hollenberg, LCL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18777-18782 , 文章类型: Article,,卷期:2010年107-44]
- In drug discovery, there is a clear and urgent need for detection of cell-membrane ion-channel operation with wide-field capability. Existing techniques are generally invasive or require specialized nanostructures. We sh...
- Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
[作者:Clemons, PA; Bodycombe, NE; Carrinski, HA; Wilson, JA; Shamji, AF; Wagner, BK; Koehler, AN; Schreiber, SL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18787-18792 , 文章类型: Article,,卷期:2010年107-44]
- Using a diverse collection of small molecules generated from a variety of sources, we measured protein-binding activities of each individual compound against each of 100 diverse (sequence-unrelated) proteins using small-...
- High-performance continuous-wave room temperature 4.0-mu m quantum cascade lasers with single-facet optical emission exceeding 2 W
[作者:Lyakh, A; Maulini, R; Tsekoun, A; Go, R; Von der Porten, S; Pflugl, C; Diehl, L; Capasso, F; Patel, CKN,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18799-18802 , 文章类型: Article,,卷期:2010年107-44]
- A strain-balanced, AlInAs/InGaAs/InP quantum cascade laser structure, designed for light emission at 4.0 mu m using nonresonant extraction design approach, was grown by molecular beam epitaxy. Laser devices were processe...
- Evidence for a bimodal distribution in human communication
[作者:Wu, Y; Zhou, CS; Xiao, JH; Kurths, J; Schellnhuber, HJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18803-18808 , 文章类型: Article,,卷期:2010年107-44]
- Interacting human activities underlie the patterns of many social, technological, and economic phenomena. Here we present clear empirical evidence from Short Message correspondence that observed human actions are the res...
- Universal robotic gripper based on the jamming of granular material
[作者:Brown, E; Rodenberg, N; Amend, J; Mozeika, A; Steltz, E; Zakin, MR; Lipson, H; Jaeger, HM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18809-18814 , 文章类型: Article,,卷期:2010年107-44]
- Gripping and holding of objects are key tasks for robotic manipulators. The development of universal grippers able to pick up unfamiliar objects of widely varying shape and surface properties remains, however, challengin...
- Thirty thousand-year-old evidence of plant food processing
[作者:Revedin, A; Aranguren, B; Becattini, R; Longo, L; Marconi, E; Lippi, MM; Skakun, N; Sinitsyn, A; Spiridonova, E; Svoboda, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18815-18819 , 文章类型: Article,,卷期:2010年107-44]
- European Paleolithic subsistence is assumed to have been largely based on animal protein and fat, whereas evidence for plant consumption is rare. We present evidence of starch grains from various wild plants on the surfa...
|