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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   1,6-Conjugate Addition of Nucleophiles to alpha,beta,gamma,delta-Diunsaturated Systems [作者：SILVA EDUARDA M P; SILVA ARTUR M S,期刊：Synthesis, 页码：3109-3128 , 文章类型： Review，,卷期：2012年44-20] Herein, an overview of the most important developments and concepts related to the 1,6-conjugate addition reactions are reviewed. 1 Introduction 2 Transition-Metal-Catalyzed 1,6-Conjugate Additions 2.1 Copper-Mediated Re... A Facile Method for the Synthesis of 3-Substituted 3-(Alkylthio)oxindoles or 3-Alkoxyoxindoles [作者：ZHU FENG; ZHOU FENG; CAO ZHONGYAN; WANG CHAO; ZHANG YONGXUE; WANG CUIHONG; ZHOU JIAN,期刊：Synthesis, 页码：3129-3144 , 文章类型： Article，,卷期：2012年44-20] We report a highly efficient perchloric acid catalyzed substitution reaction of 3-hydroxyoxindoles with thiols and alcohols for the synthesis of 3-substituted 3-(alkylthio)oxindoles or 3-alkoxyoxindoles, with catalyst lo... Efficient Preparation of 1,3-Diol Derivatives with Three Contiguous Stereo-centers by an Enantioselective Direct Aldol-Tishchenko Reaction [作者：ICHIBAKASE TOMONORI; NAKAJIMA MAKOTO,期刊：Synthesis, 页码：3145-3151 , 文章类型： Article，,卷期：2012年44-20] 1,3-Diol derivatives with three contiguous stereocenters were efficiently prepared by an enantioselective direct aldol-Tishchenko reaction catalyzed by dilithium 3,3'-diphenylbinaphtholate. The reactions of acyclic keton... Efficient Synthesis of 4-Amino-2-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-ones: Practical Access to a Novel Chemotype in the Development of DGAT-1 Inhibitors [作者：BAHNCK KEVIN B; SHAVNYA ANDREI; TAO YONG; LILLEY SUSAN C; ANDREWS MELISSA P; ASPNES GARY E; BERNHARDSON DAVID J; BILL DAVID R; BUNDESMANN MARK W; DOW ROBERT L; KARKI KAPIL; LE TUNG; LI QIFANG; MUNCHHOF MICHAEL J; NEMATALLA ASAAD; NIHLAWI MOHAMMED; PATEL LEENA; PERREAULT CHRISTIAN; WALDO MICHAEL,期刊：Synthesis, 页码：3152-3157 , 文章类型： Article，,卷期：2012年44-20] A practical access to an unprecedented, fused bicyclic 4-amino-2-alkoxy-7,8-dihydropyrido[4,3-d]pyrimidin-5-one scaffold is developed. The synthesis of the potent inhibitor, 2-{4-[4-amino-2-methoxy-5-oxo-7,8-dihydropyrid... Synthesis of 2,4,6-Triazidopyridine and Its 3,5-Diiodo Derivative [作者：CHAPYSHEV SERGEI V; CHERNYAK ALEXANDER V,期刊：Synthesis, 页码：3158-3160 , 文章类型： Article，,卷期：2012年44-20] 2,4,6-Trifluoropyridine was diiodinated with a mixture of potassium iodide and periodic acid in sulfuric acid at 55 degrees C to give 2,4,6-trifluoro-3,5-diiodopyridine in 85% yield. Both the starting trifluoropyridine a... Heck Reaction of Baylis-Hillman Adducts with Iodobenzenes Using a Catalytic Amount of Pd/C under Solvent-Free Conditions [作者：KIM HYUNSOO; LEE SANGJIN; CHOI BORAM; YOON CHEOL MIN,期刊：Synthesis, 页码：3161-3164 , 文章类型： Article，,卷期：2012年44-20] The reaction of Baylis-Hillman adducts with iodobenzenes using commercially available palladium-on-carbon as a catalyst under solvent-free conditions afforded the corresponding coupling products, alpha-benzyl-beta-keto e... Highly Improved Copper-Mediated Michael Addition of Ethyl Bromodifluoroacetate in the Presence of Protic Additive [作者：KIM BONG CHAN; PARK AERI; AN JI EUN; LEE WON KOO; LEE HEE BONG; SHIN HYUNIK,期刊：Synthesis, 页码：3165-3170 , 文章类型： Article，,卷期：2012年44-20] Copper-mediated Michael addition of ethyl bromodifluoroacetate to Michael acceptors is accompanied by the formation of a substantial amount of byproducts. Elucidation of their structure hinted the cause of their formatio... A Practical Synthesis of (S)-tert-Butyl 3-Methyl-1,4-diazepane-1-carboxylate, the Key Intermediate of Rho-Kinase Inhibitor K-115 [作者：GOMI NORIAKI; KOUKETSU AKIYASU; OHGIYA TADAAKI; SHIBUYA KIMIYUKI,期刊：Synthesis, 页码：3171-3178 , 文章类型： Article，,卷期：2012年44-20] A practical synthesis of (S)-tert-butyl 3-methyl-1,4-diazepane-1-carboxylate has been established for supplying this key intermediate of Rho-kinase inhibitor K-115 in a multikilogram production. The chiral 1,4-diazepane ... Functionalized Carbodiimide Mediated Synthesis of 2,3-Disubstituted Quinazolin-4(3H)-ones via the Tandem Strategy of C-Nucleophilic Addition and Intramolecular NH-Substitution Cyclization [作者：NAKANO HAYATO; KUTSUMURA NORIKI; SAITO TAKAO,期刊：Synthesis, 页码：3179-3184 , 文章类型： Article，,卷期：2012年44-20] A facile synthesis of quinazolin-4(3H)-ones possessing carbon substituents at positions 2 and 3 has been developed. Key to the synthesis is a tandem strategy involving introduction of a 2-substituent and construction of ... Convenient Methods to Access Chiral Camphanyl Amine Derivatives by Sodium Borohydride Reduction of D-(-)-Camphorquinone Imines [作者：PERIASAMY MARIAPPAN; SANJEEVAKUMAR NALLURI; REDDY POLIMERA OBULA,期刊：Synthesis, 页码：3185-3190 , 文章类型： Article，,卷期：2012年44-20] D-(-)-Camphorquinone imines prepared using methanolic ammonia, ethanol amine, exo-(-)-bornylamine, ethylene diamine, propylene diamine, and trans-(R, R)-1,2-diaminocyclohexane, upon reduction using sodium borohydride in ... Catalyst-Free Amidation of Trimethylsilyl Ketene Imines with Isocyanates [作者：QIN WENLING; LONG SHA; PANUNZIO MAURO; BONGINI ALESSANDRO,期刊：Synthesis, 页码：3191-3196 , 文章类型： Article，,卷期：2012年44-20] A catalyst-free method for the amidation of N-trimethylsilyl ketene imines using isocyanates is reported. A working hypothesis on the reaction pathway includes silatropism from the ketene nitrogen to the isocyanate oxyge... Synthesis of gamma,delta-Unsaturated Selenoamides via the Seleno-Claisen Rearrangement of in situ Generated Allylic Vinyl Selenides from Selenoamides and Allylic Bromides [作者：MURAI TOSHIAKI; EZAKA TATSUYA; KATO SHINZI,期刊：Synthesis, 页码：3197-3201 , 文章类型： Article，,卷期：2012年44-20] The deprotonation of alpha-monosubstituted selenoamides with LDA followed by allylation gives gamma,delta-unsaturated selenoamides in good to high yields. In the initial step, allylation may take place at the selenium at... BF3 center dot OEt2/TMSN3 Mediated Regioselective Azidolysis of Vinylaziridines [作者：RIGHI GIULIANA; BOVICELLI PAOLO; MARUCCI CRISTINA; TIROTTA ILARAI,期刊：Synthesis, 页码：3202-3208 , 文章类型： Article，,卷期：2012年44-20] An easy and general azidolysis of vinylepoxides mediated by BF3 center dot OEt2 and TMSN3 recently reported by our group has been extended to vinylaziridines. The reaction affords unsaturated azido derivatives with compl... Development of Tartaric Acid Derived Hydrogen-Bond Donors [作者：LAUBER MARKUS BORIS; FROEHLICH ROLAND; PARADIES JAN,期刊：Synthesis, 页码：3209-3215 , 文章类型： Article，,卷期：2012年44-20] A flexible synthesis of bifunctional thiourea derivatives based on the TADDOL framework is described. Hydroxy as well as primary, secondary, and tertiary amino-substituted bifunctional hydrogen-bond donors were synthesiz... Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8 [作者：IBRAHIM MOHAMED A; BLAISE EMILIE; LOZACH OLIVIER; SZALATA CLAUDE; SCHMITT MARTINE; ELETRAWY ABDALLAH S; ELAGAWANY MOHAMED; ELFEKY SAID A; ABDELSAMII ZAKRAIA K; MEIJER LAURENT; BOURGUIGNON JEANJACQUES; BIHEL FREDERIC,期刊：Synthesis, 页码：3216-3224 , 文章类型： Article，,卷期：2012年44-20] Several synthetic strategies were developed for the preparation of highly substituted pyrido[2,3-d]pyridazines. We particularly focused on the impact of the pyridine nitrogen atom on pyridazine ring reactivity toward aro... Pherase-Transfer Catalysts in the O-Alkylation of 2-Hydroxynaphthoquinones [作者：LU XIAO; ALTHARAWI ALI; HANSEN EMILY N; LONG TIMOTHY E,期刊：Synthesis, 页码：3225-3230 , 文章类型： Article，,卷期：2012年44-20] A mild procedure has been developed for the O-alkylation of 2-hydroxynaphthoquinones by using phase-transfer catalysts. Optimal yields were obtained when 18-crown-6 (10 mol%) and tetrabutylammonium iodide (10 mol%) were ...