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[摘要]:Copper-mediated Michael addition of ethyl bromodifluoroacetate to Michael acceptors is accompanied by the formation of a substantial amount of byproducts. Elucidation of their structure hinted the cause of their formation, from which we discovered a highly improved and robust protocol by treatment with protic additives such as H2O and AcOH. This modification led to significant increase of yield with concomitant decreased use of reagent. |
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