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[摘要]：The deprotonation of alpha-monosubstituted selenoamides with LDA followed by allylation gives gamma,delta-unsaturated selenoamides in good to high yields. In the initial step, allylation may take place at the selenium atom of lithium eneselenolates to form allylic vinyl selenides, which then undergo seleno-Claisen rearrangement. As allylic bromides gamma,gamma-disubstituted compounds such as geranyl and neryl bromides could also be used to give products that incorporated tertiary-quaternary stereogenicity with high efficiency. |
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