- More than one way to make a tail
[作者：Marzluff, WF,期刊：EMBO journal, 页码：4066-4067 , 文章类型： Editorial Material，,卷期：2010年29-24]
- The vast majority of eukaryotic messenger mRNAs undergo 3' end cleavage and polyadenylation. The noncanonical poly(A) polymerase (PAP), STAR-PAP, adds a poly(A) tail to specific transcripts under oxidative stress conditi...
- Nuclear FoxO1 inflames insulin resistance
[作者：Dominy, JE; Puigserver, P,期刊：EMBO journal, 页码：4068-4069 , 文章类型： Editorial Material，,卷期：2010年29-24]
- Chronic activation of macrophage-mediated inflammatory signals in insulin-sensitive metabolic tissues is thought to be one of the causes of insulin resistance-one of the hallmarks of the metabolic syndrome. However, the ...
- Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p
[作者：Sato, Y; Shibata, H; Nakatsu, T; Nakano, H; Kashiwayama, Y; Imanaka, T; Kato, H,期刊：EMBO journal, 页码：4083-4093 , 文章类型： Article，,卷期：2010年29-24]
- Peroxisomes require peroxin (Pex) proteins for their biogenesis. The interaction between Pex3p, which resides on the peroxisomal membrane, and Pex19p, which resides in the cytosol, is crucial for peroxisome formation and...
- Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells
[作者：Silhankova, M; Port, F; Harterink, M; Basler, K; Korswagen, HC,期刊：EMBO journal, 页码：4094-4105 , 文章类型： Article，,卷期：2010年29-24]
- Wnt proteins are lipid-modified glycoproteins that have important roles in development, adult tissue homeostasis and disease. Secretion of Wnt proteins from producing cells is mediated by the Wnt-binding protein MIG-14/W...
- The tumour suppressor C/EBP delta inhibits FBXW7 expression and promotes mammary tumour metastasis
[作者：Balamurugan, K; Wang, JM; Tsai, HH; Sharan, S; Anver, M; Leighty, R; Sterneck, E,期刊：EMBO journal, 页码：4106-4117 , 文章类型： Article，,卷期：2010年29-24]
- Inflammation and hypoxia are known to promote the metastatic progression of tumours. The CCAAT/enhancer-binding protein-delta (C/EBP delta, CEBPD) is an inflammatory response gene and candidate tumour suppressor, but its...
- ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice
[作者：Yalcin, S; Marinkovic, D; Mungamuri, SK; Zhang, X; Tong, W; Sellers, R; Ghaffari, S,期刊：EMBO journal, 页码：4118-4131 , 文章类型： Article，,卷期：2010年29-24]
- Reactive oxygen species (ROS) participate in normal intracellular signalling and in many diseases including cancer and aging, although the associated mechanisms are not fully understood. Forkhead Box O (FoxO) 3 transcrip...
- Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing
[作者：Huntzinger, E; Braun, JE; Heimstadt, S; Zekri, L; Izaurralde, E,期刊：EMBO journal, 页码：4146-4160 , 文章类型： Article，,卷期：2010年29-24]
- miRNA-mediated gene silencing requires the GW182 proteins, which are characterized by an N-terminal domain that interacts with Argonaute proteins (AGOs), and a C-terminal silencing domain (SD). In Drosophila melanogaster...
- c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
[作者：Dynek, JN; Goncharov, T; Dueber, EC; Fedorova, AV; Izrael-Tomasevic, A; Phu, L; Helgason, E; Fairbrother, WJ; Deshayes, K; Kirkpatrick, DS; Vucic, D,期刊：EMBO journal, 页码：4198-4209 , 文章类型： Article，,卷期：2010年29-24]
- Ubiquitin ligases are critical components of the ubiquitination process that determine substrate specificity and, in collaboration with E2 ubiquitin-conjugating enzymes, regulate the nature of polyubiquitin chains assemb...
- FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
[作者：Fan, WQ; Morinaga, H; Kim, JJ; Bae, E; Spann, NJ; Heinz, S; Glass, CK; Olefsky, JM,期刊：EMBO journal, 页码：4223-4236 , 文章类型： Article，,卷期：2010年29-24]
- The macrophage-mediated inflammatory response is a key etiologic component of obesity-related tissue inflammation and insulin resistance. The transcriptional factor FoxO1 is a key regulator of cell metabolism, cell cycle...
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