| |
[摘要]：Chronic activation of macrophage-mediated inflammatory signals in insulin-sensitive metabolic tissues is thought to be one of the causes of insulin resistance-one of the hallmarks of the metabolic syndrome. However, the mechanisms, components and dynamics by which this inflammatory response is spatially and temporally regulated are not completely understood. In this issue of The EMBO Journal, Olefsky and colleagues (Fan et al, 2010) report that FoxO1, which is suppressed by the action of AKT, triggers the Tlr4 inflammatory signalling pathway in macrophages. The authors further establish that inflammatory signalling pathways are also able to signal back to and suppress the activity of FoxO1 through AKT. The findings of this paper suggest an intriguing regulatory transcriptional/signalling loop in macrophages that may contribute to maintain and exacerbate inflammation and insulin resistance in other cell types such as adipocytes. |
|
