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[摘要]：The vast majority of eukaryotic messenger mRNAs undergo 3' end cleavage and polyadenylation. The noncanonical poly(A) polymerase (PAP), STAR-PAP, adds a poly(A) tail to specific transcripts under oxidative stress conditions. These transcripts have the AAUAAA polyadenylation signal and use the same factors for cleavage, but are not polyadenylated by the canonical polyA polymerase. In this issue of The EMBO Journal, Leishram and Anderson ask what determinants are required for the modification of specific mRNAs by STAR-PAP. They report a surprising role for STAR-PAP in binding to the pre-mRNA and recruiting the processing factors required for cleavage, which suggests that there is still much to be discovered regarding the regulation of 3'end processing. |
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