- Decreased S-Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness (July, pg 117, 2010)
[作者:Santhanam, L; Tuday, EC; Webb, AK; Dowzicky, P; Kim, JH; Oh, YJ; Sikka, G; Kuo, M; Halushka, MK; Macgregor, AM; Dunn, J; Gutbrod, S; Yin, D; Shoukas, A; Nyhan, D; Flavahan, NA; Belkin, AM; Berkowitz, DE,期刊:Circulation Research, 页码:E12-E12 , 文章类型: Correction,,卷期:2011年108-9]
-
- Evidence for Pleiotropic Effects of Phosphodiesterase-5 (PDE5) Inhibitors: Emerging Concepts in Cancer and Cardiovascular Medicine
[作者:Gross, GJ,期刊:Circulation Research, 页码:1040-1041 , 文章类型: Editorial Material,,卷期:2011年108-9]
- A new study reports that the PDE5 inhibitor, sildenafil, enhances the chemotherapeutic efficacy of the anticancer drug, doxorubicin (DOX), in prostate and other cancer cell lines, while alleviating the commonly observed ...
- FKBP12 Is a Critical Regulator of the Heart Rhythm and the Cardiac Voltage-Gated Sodium Current in Mice
[作者:Maruyama, M; Li, BY; Chen, HY; Xu, XH; Song, LS; Guatimosim, S; Zhu, WQ; Yong, WD; Zhang, WJ; Bu, GX; Lin, SF; Fishbein, MC; Lederer, WJ; Schild, JH; Field, LJ; Rubart, M; Chen, PS; Shou, WN,期刊:Circulation Research, 页码:1042-U38 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: FK506 binding protein (FKBP) 12 is a known cis-trans peptidyl prolyl isomerase and highly expressed in the heart. Its role in regulating postnatal cardiac function remains largely unknown. Methods and Results:...
- Peptide-Mediated Disruption of Calmodulin-Cyclin E Interactions Inhibits Proliferation of Vascular Smooth Muscle Cells and Neointima Formation
[作者:Hui, S; Choi, J; Zaidi, S; Momen, A; Steinbach, SK; Sadi, AM; Ban, K; Husain, M,期刊:Circulation Research, 页码:1053-U69 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: Cell cycle progression in vascular smooth muscle cells (VSMCs) is a therapeutic target for restenosis. Objective: Having discovered that calmodulin (CaM)-dependent cyclin E/CDK2 activity underlies Ca2+ -sensit...
- Local Retention Versus Systemic Release of Soluble VEGF Receptor-1 Are Mediated by Heparin-Binding and Regulated by Heparanase
[作者:Sela, S; Natanson-Yaron, S; Zcharia, E; Vlodavsky, I; Yagel, S; Keshet, E,期刊:Circulation Research, 页码:1063-U83 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: The vascular endothelial growth factor (VEGF) decoy receptor soluble VEGF-R1 (sVEGF-R1) is thought to protect the cells that produce it from adverse VEGF signaling. To accomplish this role, a mechanism for per...
- The Ephrin A1-EphA2 System Promotes Cardiac Stem Cell Migration After Infarction
[作者:Goichberg, P; Bai, YN; D'Amario, D; Ferreira-Martins, J; Fiorini, C; Zheng, HQ; Signore, S; del Monte, F; Ottolenghi, S; D'Alessandro, DA; Michler, RE; Hosoda, T; Anversa, P; Kajstura, J; Rota, M; Leri, A,期刊:Circulation Research, 页码:1071-U114 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: Understanding the mechanisms that regulate trafficking of human cardiac stem cells (hCSCs) may lead to development of new therapeutic approaches for the failing heart. Objective: We tested whether the motility...
- A Novel Hypoxia-Inducible Spliced Variant of Mitochondrial Death Gene Bnip3 Promotes Survival of Ventricular Myocytes
[作者:Gang, HY; Hai, Y; Dhingra, R; Gordon, JW; Yurkova, N; Aviv, Y; Li, HZ; Aguilar, F; Marshall, A; Leygue, E; Kirshenbaum, LA,期刊:Circulation Research, 页码:1084-1092 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: Alternative splicing provides a versatile mechanism by which cells generate proteins with different or even antagonistic properties. Previously, we established hypoxia-inducible death factor Bnip3 as a critica...
- Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition
[作者:Egorova, AD; Khedoe, PPSJ; Goumans, MJTH; Yoder, BK; Nauli, SM; ten Dijke, P; Poelmann, RE; Hierck, BP,期刊:Circulation Research, 页码:1093-U142 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow. In endothelial cells (ECs), they function by transducing local blood flow information into functional responses, such as nitr...
- A Novel Role for Calpain in the Endothelial Dysfunction Induced by Activation of Angiotensin II Type 1 Receptor Signaling
[作者:Scalia, R; Gong, YL; Berzins, B; Freund, B; Feather, D; Landesberg, G; Mishra, G,期刊:Circulation Research, 页码:1102-U163 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: The cytosolic protease calpain has been recently implicated in the vascular remodeling of angiotensin II (Ang II) type 1 receptor (AT(1)R) signaling. The role of Ang II/AT(1)R/calpain signaling on endothelial ...
- Widespread Increase in Myeloid Calcifying Cells Contributes to Ectopic Vascular Calcification in Type 2 Diabetes
[作者:Fadini, GP; Albiero, M; Menegazzo, L; Boscaro, E; de Kreutzenberg, SV; Agostini, C; Cabrelle, A; Binotto, G; Rattazzi, M; Bertacco, E; Bertorelle, R; Biasini, L; Mion, M; Plebani, M; Ceolotto, G; Angelini, A; Castellani, C; Menegolo, M; Grego, F; Dimmeler,期刊:Circulation Research, 页码:1112-1121 , 文章类型: Article,,卷期:2011年108-9]
- Rationale: Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification of atherosclerotic plaques, which is common in diabetes. Objective: We aim to identify and characterize ci...
|