- Double Down for a Double Win
[作者：Huang, PS,期刊：Clinical Cancer Research, 页码：2124-2126 , 文章类型： Editorial Material，,卷期：2012年18-8]
- The rationale for using multiple inhibitors between and within the phosphoinositide 3-kinase/AKT/mTOR and RAS/MEK/ERK pathways is scientifically compelling, and a limited number of experimental agents are currently being...
- Novel Therapeutic Agents for the Management of Patients with Multiple Myeloma and Renal Impairment
[作者：Chanan-Khan, AA; San Miguel, JF; Jagannath, S; Ludwig, H; Dimopoulos, MA,期刊：Clinical Cancer Research, 页码：2145-2163 , 文章类型： Review，,卷期：2012年18-8]
- Renal impairment is a major complication of multiple myeloma. Patients presenting with severe renal impairment represent a greater therapeutic challenge and generally have poorer outcome. However, once patients with rena...
- Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL
[作者：Kanemitsu, N; Isobe, Y; Masuda, A; Momose, S; Higashi, M; Tamaru, J; Sugimoto, K; Komatsu, N,期刊：Clinical Cancer Research, 页码：2164-2172 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: Extranodal NK/T-cell lymphoma, nasal type (ENKL) is closely associated with Epstein-Barr virus (EBV). To elucidate its pathogenetic role, we examined the expression profiles of EBV-encoded proteins, especially f...
- Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma
[作者：Malkoski, SP; Haeger, SM; Cleaver, TG; Rodriguez, KJ; Li, H; Lu, SL; Feser, WJ; Baron, AE; Merrick, D; Lighthall, JG; Ijichi, H; Franklin, W; Wang, XJ,期刊：Clinical Cancer Research, 页码：2173-2183 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: Lung adenocarcinoma and lung squamous cell carcinoma (SCC) are the most common non-small cell lung cancer (NSCLC) subtypes. This study was designed to determine whether reduced expression of TGF beta type II rec...
- RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors
[作者：Su, YJ; Vilgelm, AE; Kelley, MC; Hawkins, OE; Liu, Y; Boyd, KL; Kantrow, S; Splittgerber, RC; Short, SP; Sobolik, T; Zaja-Milatovic, S; Dahlman, KB; Amiri, KI; Jiang, AX; Lu, PC; Shyr, Y; Stuart, DD; Levy, S; Sosman, JA; Richmond, A,期刊：Clinical Cancer Research, 页码：2184-2198 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: The purpose of this preclinical study was to determine the effectiveness of RAF265, a multikinase inhibitor, for treatment of human metastatic melanoma and to characterize traits associated with drug response. E...
- Stem-like Tumor-Initiating Cells Isolated from IL13R alpha 2 Expressing Gliomas Are Targeted and Killed by IL13-Zetakine-Redirected T Cells
[作者：Brown, CE; Starr, R; Aguilar, B; Shami, AF; Martinez, C; D'Apuzzo, M; Barish, ME; Forman, SJ; Jensen, MC,期刊：Clinical Cancer Research, 页码：2199-2209 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: To evaluate IL13R alpha 2 as an immunotherapeutic target for eliminating glioma stem-like cancer initiating cells (GSC) of high-grade gliomas, with particular focus on the potential of genetically engineered IL1...
- Aurora A Inhibitor (MLN8237) plus Vincristine plus Rituximab Is Synthetic Lethal and a Potential Curative Therapy in Aggressive B-cell Non-Hodgkin Lymphoma
[作者：Mahadevan, D; Stejskal, A; Cooke, LS; Manziello, A; Morales, C; Persky, DO; Fisher, RI; Miller, TP; Qi, WQ,期刊：Clinical Cancer Research, 页码：2210-2219 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: Aurora A and B are oncogenic serine/threonine kinases that regulate mitosis. Overexpression of Auroras promotes resistance to microtubule-targeted agents. We investigated mechanistic synergy by inhibiting the mi...
- First Evidence That gamma-Tocotrienol Inhibits the Growth of Human Gastric Cancer and Chemosensitizes It to Capecitabine in a Xenograft Mouse Model through the Modulation of NF-kappa B Pathway
[作者：Manu, KA; Shanmugam, MK; Ramachandran, L; Li, F; Fong, CW; Kumar, AP; Tan, P; Sethi, G,期刊：Clinical Cancer Research, 页码：2220-2229 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: Because of poor prognosis and development of resistance against chemotherapeutic drugs, the existing treatment modalities for gastric cancer are ineffective. Hence, novel agents that are safe and effective are u...
- The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin
[作者：Lemaire, M; Fristedt, C; Agarwal, P; Menu, E; Van Valckenborgh, E; De Bruyne, E; Osterborg, A; Atadja, P; Larsson, O; Axelson, M; Van Camp, B; Jernberg-Wiklund, H; Vanderkerken, K,期刊：Clinical Cancer Research, 页码：2230-2239 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: We have previously shown the use of the insulin-like growth factor type 1 receptor tyrosine kinase (IGF-1RTK) inhibitor picropodophyllin (PPP) as an attractive strategy to combat multiple myeloma (MM) in vitro a...
- Cytokine BAFF Gene Variation Is Associated with Survival of Patients with T-cell Lymphomas
[作者：Zhai, K; Tian, XB; Wu, C; Lu, N; Chang, J; Huang, LM; Zhang, TW; Zhou, YL; Qiao, Y; Yu, DK; Tan, W; Chen, JP; Lin, DX,期刊：Clinical Cancer Research, 页码：2250-2256 , 文章类型： Article，,卷期：2012年18-8]
- Purpose: Cytokine BAFF is a potent molecule for the activation and survival of B cells, and it also plays an important role in T-cell function. Genetic polymorphism (rs9514828C>T) in BAFF has been associated with elevate...
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