Choosing Phase II Endpoints and Designs: Evaluating the Possibilities

[摘要]：Selecting the phase II design and endpoint to achieve the best possible chance of success for a confirmatory phase III study in a particular disease and treatment setting is challenging but critical. Simulating from existing clinical trial data sets and from mathematical models can be useful tools for evaluating statistical properties. Clin Cancer Res; 18(8); 2130-2. (C) 2012 AACR.

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