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[摘要]：Patients with non-small cell lung carcinoma containing epidermal growth factor receptor (EGFR)activating mutations benefit from EGFR-antagonist therapy. EGFR-antagonist sensitivity is also correlated with epithelial-mesenchymal transition, which Walter and colleagues show to be marked by DNA-methylation changes. If validated, these markers could help identify patients with wild-type EGFR who will benefit from EGFR therapy. Clin Cancer Res; 18(8); 2121-3. (C) 2012 AACR. |
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