Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor

[摘要]：We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内