外文期刊订阅>期刊> Journal of Medicinal Chemistry

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  出版社: AMERICAN CHEMICAL SOCIETY
  期刊类型: 半月刊
  影响因子: 4.802
  ISSN: 0022-2623
  所在领域: 化学化工    药物研发   
 
 

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

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The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

Some specific areas that are appropriate include the following:

  • Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.
  • Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.
  • Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.
  • Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.
  • Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.
  • Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.
  • Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.
  • Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

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Journal of Medicinal Chemistry

中文名:   缩写名: J. Med. Chem.

收入刊期 2013年   2012年   2011年   2010年   2009年   2008年  

最新期2013年56-2期内容

1 Synthesis and Biological Evaluation of 5-Benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione Derivatives for the Treatment of Obesity-Related Nonalcoholic Fatty Liver Disease (vol 55, pg 9958, 2012)
2 Structure-Activity Relationship Study of N-6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N-6-propyl-4,5,6,7-tetrah ydrobenzo[d]thiazole-2,6-diamine Analogues: Development of Highly Selective D3 Dopamine Receptor Agonists along with a Highly Potent D2/D3 Agonist and Their Pharmacological Characterization (vol 55, pg 5826, 2012)
3 Structure-Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.(1) Reversed Enantioselectivity of 1,4-Dioxane Derivatives in alpha(1)-Adrenergic and 5-HT1A Receptor Binding Sites Recognition
4 Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome
5 N-Cinnamoylated Chloroquine Analogues as Dual-Stage Antimalarial Leads
6 Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors
7 Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
8 Development of New Cathepsin B Inhibitors: Combining Bioisosteric Replacements and Structure-Based Design To Explore the Structure-Activity Relationships of Nitroxoline Derivatives
9 Synthesis and SAR of Novel Re/Tc-99m-Labeled Benzenesulfonamide Carbonic Anhydrase IX Inhibitors for Molecular Imaging of Tumor Hypoxia
10 New Bis-thiazolium Analogues as Potential Antimalarial Agents: Design, Synthesis, and Biological Evaluation
11 Total Synthesis and Evaluation of Vinblastine Analogues Containing Systematic Deep-Seated Modifications in the Vindoline Subunit Ring System: Core Redesign
12 Novel Cyclopentadienyl Tricarbonyl Complexes of Tc-99m Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for beta-Amyloid Plaques in Brain
13 Tetrahydropyrroloquinolinone Type Dual Inhibitors of Aromatase/Aldosterone Synthase as a Novel Strategy for Breast Cancer Patients with Elevated Cardiovascular Risks
14 Aromatic Bis-N-hydroxyguanidinium Derivatives: Synthesis, Biophysical, and Biochemical Evaluations
15 Alkylsulfanyl-1,2,4-triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure-Activity Relationships
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