Identification of G protein-coupled receptor 120-selective agonists derived from PPARg agonists.

[摘要]：A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor g (PPARg) agonist 3. Modification based on the homol. model of GPR120 led to the first GPR120-selective agonist 12. These results provide a basis for constructing new tools for probing the biol. of GPR120 and for developing new candidate therapeutic agents.

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