[摘要]：1, 22 An efficient synthesis involving a key aldol reaction and biol. properties of a series of 1,3-diphenyl-2-propen-1-ones is described. The in vitro activity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging of I and II (R1 = R2 = R3 = F) was 2 times higher than that for resveratrol. Compds. I (R1 = R2 = R3 = H; R1 = R2 = R3 = F) were the strongest in suppression of in vitro nitric oxide (NO) generation and antiexcitotoxicity. Mol. modeling proposes an electron-donating group at the para position of acetophenones that leads to a dramatic increase in the suppression of NO prodn.
