Design, Synthesis, and Structure-Activity Relationships of Novel Insulin Receptor Tyrosine Kinase Activators.
作者
Lum, Robert T.;Cheng, Mingshan;Cristobal, Cristina P.;Goldfine, Ira D.;Evans, Joseph L.;Keck, James G.;Macsata, Robert W.;Manchem, Vara Prasad;Matsumoto, Yukiharu;Park, Sophia J.;Rao, Sandhya S.;Robinson, Louise;Shi, Songyuan;Spevak, Wayne R.;Schow, Steve
[摘要]：A novel series of sym. ureas of [(7-amino(2-naphthyl))sulfonyl]phenylamines, e.g., I, were designed, synthesized, and tested for their ability to increase glucose transport in mouse 3T3-L1 adipocytes, a surrogate readout for activation of the insulin receptor (IR) tyrosine kinase (IRTK). A structure-activity relationship was established that indicated glucose transport activity was dependent on the presence of two acidic functionalities, two sulfonamide linkages, and a central urea or 2-imidazolidinone core. Compd. I was identified as a potent and selective IRTK activator. At low concns., I was able to increase the tyrosine phosphorylation of the IR stimulated by submaximal insulin. At higher concns., I was able to increase tyrosine the phosphorylation levels of the IR in the absence of insulin. When administered i.p. (i.p.) and orally (po), I improved glucose tolerance in hypoinsulinemic, streptozotocin-treated rats. These data provide pharmacol. validation that small mol. IRTK activators represent a potential new class of antidiabetic agents.
