Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, b Amyloid Aggregation, and Ab Neurotoxicity.

[摘要]：The complex etiol. of Alzheimer's disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid mols. I (R = H, COMe, COPh, etc.) linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Ab fibril formation for I (R = H, COPh, COC6H4Me-4). I (R = COPh) showed an addnl. neuroprotective effect.

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