[摘要]:(Biomolecules and Their Synthetic Analogs) Section Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive SAR anal. of satd. and unsatd. chalcone synthetic intermediates, led to the identification of analogs with selective and significant in vitro anti-Trypanosoma cruzi activity. Further SAR studies were undertaken with the synthesis of 21 new chalcones contg. two allyloxy moieties that resulted in the discovery of 2',4'-diallyloxy-6'-methoxy chalcones with improved selectivity against this parasite at concns. below 25 mM, four of which exhibited a selectivity index greater than 12.