【文章名】The Design, Synthesis, and Antiviral Activity of 4'-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4'-Azidoarabinocytidine.
The Design, Synthesis, and Antiviral Activity of 4'-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4'-Azidoarabinocytidine.
[摘要]:and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here the synthesis and biol. evaluation of several derivs. of 4'-azidocytidine by varying the substituents at the ribose 2' and 3'-positions are described. The most potent compd. in this series is 4'-azidoarabinocytidine with an IC50 of 0.17 mM in the genotype 1b subgenomic replicon system. The structure-activity relationships within this series of nucleoside analogs are discussed.