【文章名】Design and Synthesis of a Cyclic Double Mutant Peptide (cyclo(87-99)[A91,A96]MBP87-99) Induces Altered Responses in Mice after Conjugation to Mannan: Implications in the Immunotherapy of Multiple Sclerosis.
Design and Synthesis of a Cyclic Double Mutant Peptide (cyclo(87-99)[A91,A96]MBP87-99) Induces Altered Responses in Mice after Conjugation to Mannan: Implications in the Immunotherapy of Multiple Sclerosis.
[摘要]：Altered peptide ligands that alter immune responses are a promising approach to the immunotherapy of multiple sclerosis. Cyclic peptides are of interest because the limited stability of linear peptides restricts their use in vivo. The authors designed and synthesized a cyclic double mutant peptide from cyclo[A91,A96]MBP87-99 (MBP = myelin basic protein). Immunization of mice, in CFA reduced Th1 responses. However, when conjugated to reduced mannan via KLH (keyhole limpet hemocyanin) as a linker, a significant further redn. of Th1 responses and moderate Th2 responses were induced.
