【文章名】Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides.
Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides.
作者
Moore, William J.;Kern, Jeffrey C.;Bhat, Ramesh;Commons, Thomas J.;Fukayama, Shoichi;Goljer, Igor;Krishnamurthy, Girija;Magolda, Ronald L.;Nogle, Lisa;Pitts, Keith;Stauffer, Barb;Trybulski, Eugene J.;Welmaker, Gregory S.;Wilson, Matthew;Bodine, Peter V. N
[摘要]：The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small mol. inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic agents for the treatment of osteoporosis or other bone-related disorders. Details of the structure-activity relationships and biol. activity from the first structural class of this scaffold will be discussed.
