【文章名】Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development
Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development
作者
WITTMAN MARK D; CARBONI JOAN M; YANG ZHENG; LEE FRANCIS Y; ANTMAN MELISSA; ATTAR RICARDO; BALIMANE PRAVEEN; CHANG CHIEHYING; CHEN CLIFF; DISCENZA LORELL; FRENNESSON DAVID; GOTTARDIS MARCO M; GREER ANN; HURLBURT WARREN; JOHNSON WALTER; LANGLEY DAVID R; LI AIXIN; LI JIANQING; LIU PEIYING; MASTALERZ HAROLD; MATHUR ARVIND; MENARD KRISTA; PATEL KARISHMA; SACK JOHN; SANG XIAOPENG; SAULNIER MARK; SMITH DANIEL; STEFANSKI KEVIN; TRAINOR GEORGE; VELAPARTHI UPENDER; ZHANG GUIFEN; ZIMMERMANN KURT; VYAS DOLATRAI M
[摘要]：This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical development.
