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Lipid-Conjugated Oligonucleotides via "Click Chemistry" Efficiently Inhibit Hepatitis C Virus Translation.

  作者 Godeau, Guilhem;Staedel, Cathy;Barthelemy, Philippe;  
  选自 期刊  Journal of Medicinal Chemistry;  卷期  2008年51-15;  页码  4374-4376  
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[摘要]uptake of oligonucleotides and allows their intracellular delivery. These nontoxic lipid conjugates efficiently inhibit hepatitis C virus internal ribosome entry site (IRES)-mediated translation in human hepatic Huh7 cells. The biol. activity of the lipid-conjugated oligonucleotides is not affected by the presence of serum.

 
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