Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists.

[摘要]：antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed rearrangement. Further modification of the A/B-ring homoallylic alc. to the conjugated ketone led to the discovery of new cyclopamine analogs, e.g. I, with ranging from 10 to 1000 nM.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内