- Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase
[作者:Yun, MK; Wu, YN; Li, ZM; Zhao, Y; Waddell, MB; Ferreira, AM; Lee, RE; Bashford, D; White, SW,期刊:Science, 页码:1110-1114 , 文章类型: Article,,卷期:2012年335-6072]
- The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have severely compromised the usefulness of thes...
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