- Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
[作者:Ravishankar, B; Liu, HY; Shinde, R; Chandler, P; Baban, B; Tanaka, M; Munn, DH; Mellor, AL; Karlsson, MCI; McGaha, TL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3909-3914 , 文章类型: Article,,卷期:2012年109-10]
- Tolerance to self-antigens present in apoptotic cells is critical to maintain immune-homeostasis and prevent systemic autoimmunity. However, mechanisms that sustain self-tolerance are poorly understood. Here we show that...
- Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication
[作者:Annes, JP; Ryu, JH; Lam, K; Carolan, PJ; Utz, K; Hollister-Lock, J; Arvanites, AC; Rubin, LL; Weir, G; Melton, DA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3915-3920 , 文章类型: Article,,卷期:2012年109-10]
- Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro-and macrovascular disease. One therapeutic strategy is to amplify insulin-secr...
- High-grade serous ovarian cancer arises from fallopian tube in a mouse model
[作者:Kim, J; Coffey, DM; Creighton, CJ; Yu, ZF; Hawkins, SM; Matzuk, MM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3921-3926 , 文章类型: Article,,卷期:2012年109-10]
- Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known about how the cancer initiates and metastasizes. In the last decade, new evidence has challenged the dogma that the ovary is the...
- Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia
[作者:Maroney, SA; Cooley, BC; Ferrel, JP; Bonesho, CE; Nielsen, LV; Johansen, PB; Hermit, MB; Petersen, LC; Mast, AE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3927-3931 , 文章类型: Article,,卷期:2012年109-10]
- Tissue factor pathway inhibitor (TFPI) blocks thrombin generation via the extrinsic blood coagulation pathway. Because the severe bleeding in patients with hemophilia occurs from deficiency of intrinsic blood coagulation...
- Homology-independent discovery of replicating pathogenic circular RNAs by deep sequencing and a new computational algorithm
[作者:Wu, QF; Wang, Y; Cao, MJ; Pantaleo, V; Burgyan, J; Li, WX; Ding, SW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3938-3943 , 文章类型: Article,,卷期:2012年109-10]
- A common challenge in pathogen discovery by deep sequencing approaches is to recognize viral or subviral pathogens in samples of diseased tissue that share no significant homology with a known pathogen. Here we report a ...
- Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
[作者:Pearce, MB; Jayaraman, A; Pappas, C; Belser, JA; Zeng, H; Gustin, KM; Maines, TR; Sun, XJ; Raman, R; Cox, NJ; Sasisekharan, R; Katz, JM; Tumpey, TM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3944-3949 , 文章类型: Article,,卷期:2012年109-10]
- Recent isolation of a novel swine-origin influenza A H3N2 variant virus [A(H3N2)v] from humans in the United States has raised concern over the pandemic potential of these viruses. Here, we analyzed the virulence, transm...
- Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus
[作者:Garnett, JA; Martinez-Santos, VI; Saldana, Z; Pape, T; Hawthorne, W; Chan, J; Simpson, PJ; Cota, E; Puente, JL; Giron, JA; Matthews, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3950-3955 , 文章类型: Article,,卷期:2012年109-10]
- Bacteria have evolved a variety of mechanisms for developing community-based biofilms. These bacterial aggregates are of clinical importance, as they are a major source of recurrent disease. Bacterial surface fibers (pil...
- PK4, a eukaryotic initiation factor 2 alpha(eIF2 alpha) kinase, is essential for the development of the erythrocytic cycle of Plasmodium
[作者:Zhang, M; Mishra, S; Sakthivel, R; Rojas, M; Ranjan, R; Sullivan, WJ; Fontoura, BMA; Menard, R; Dever, TE; Nussenzweig, V,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3956-3961 , 文章类型: Article,,卷期:2012年109-10]
- In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2 alpha(eIF2 alpha) to inhibit...
- Hypervariable loci in the human gut virome
[作者:Minot, S; Grunberg, S; Wu, GD; Lewis, JD; Bushman, FD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3962-3966 , 文章类型: Article,,卷期:2012年109-10]
- Genetic variation is critical in microbial immune evasion and drug resistance, but variation has rarely been studied in complex heterogeneous communities such as the human microbiome. To begin to study natural variation,...
- Lithium enhances remyelination of peripheral nerves
[作者:Makoukji, J; Belle, M; Meffre, D; Stassart, R; Grenier, J; Shackleford, G; Fledrich, R; Fonte, C; Branchu, J; Goulard, M; de Waele, C; Charbonnier, F; Sereda, MW; Baulieu, EE; Schumacher, M; Bernard, S; Massaad, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3973-3978 , 文章类型: Article,,卷期:2012年109-10]
- Glycogen synthase kinase 3 beta (GSK3 beta) inhibitors, especially the mood stabilizer lithium chloride, are also used as neuroprotective or anti-inflammatory agents. We studied the influence of LiCl on the remyelination...
- Rat brains also have a default mode network
[作者:Lu, HB; Zou, QH; Gu, H; Raichle, ME; Stein, EA; Yang, YH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:3979-3984 , 文章类型: Article,,卷期:2012年109-10]
- The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function (s) remains poorly unders...
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