Asymmetric mixed carboligation reactions of alpha-ketoglutarate with different aldehydes were explored with the thiamine diphosphate dependent enzymes SucA from E. coil, Kgd from Mycobacterium tuberculosis, and MenD from...
A highly efficient method for the construction of 3a,6a-dihydrofuro[2,3-b]furan derivatives has been developed via a novel bicyclization, which is very valuable for the synthesis of fused furofuran compounds since it is ...
The gold(I)/chiral Bronsted acid relay catalysis enabled a highly stereoselective three-component reaction of salicylaldehydes, anilines, and alkynols to give aromatic spiroacetals in high yields and stereoselectivities....
A novel method has been devised for the synthesis of 2,4,5-trisubstituted pyrrole derivatives through the coupling of alpha-diazoketones with beta-enaminoketones and esters using 10 mol % of Cu(OTf)(2). A wide range of 2...
An expedited method was developed for the enantioseiective synthesis of dodecahydrobenz[a]indolo[3,2-h]quinolizine containing five contiguous stereogenic centers with high enantioselectivities (>99% ee). The methodology ...
A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM...
The first example of a Piancatelli rearrangement of alcohols is demonstrated utilizing dysprosium(III) trif late as a catalyst to access oxaspirocycles in a highly diastereoselective manner. The cascade reaction construc...
Microwave irradiations allow the preparation of unsaturated bambusurils in 85% yield compared to 20% yield under classical reaction conditions. Five new bambusurils were synthesized including unsaturated derivatives Ally...
A simple three-step access to n/5/m angular tricyclic skeleta from terminal cycloalkenylacetylenes, Cr(CO)(6), and propargylmalonate esters is described. The process involves a cyclopentannulation of propargylmaionates a...
Based on a through bond energy transfer (TBET) between Rhodamlne and a naphthalimide fluorophore, a fluorescent ratiometric chemodosimeter AM was designed and prepared for single selective detection of Cu2+ in aqueous so...