Cu(OTf)(2)-Catalyzed Synthesis of 2,3-Disubstituted indoles and 2,4,5-Trisubstituted Pyrroles from alpha-Diazoketones

[摘要]：A novel method has been devised for the synthesis of 2,4,5-trisubstituted pyrrole derivatives through the coupling of alpha-diazoketones with beta-enaminoketones and esters using 10 mol % of Cu(OTf)(2). A wide range of 2,3-disubstituted indole derivatives were also prepared from alpha-diazoketones and 2-aminoaryl or alkyl ketones. The synthetic versatility of this approach has been exemplified In the formal synthesis of homofascaplysin C.

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