Photochromic spirooxazines functionalized with poly(ethylene glycol) (PEG) and poly(dimethylsiloxane) (PDMS) oligomers were monitored using NMR spectroscopy at temperatures between 193 and 233 K before and after in situ ...
The asymmetric synthesis of a carbocyclic delta-amino acid representing the P-2/P-3 subunit of a nonpeptidic truncated peptidomimetic molecule is described relying on two independent approaches.
A diastereoselective route to (+)-bakkenolide A is presented from the readily available optically active Wieland-Miescher ketone. This novel synthesis of this sesquiterpene lactone features the following as key stereosel...
Fluorescent nitrobenzoxadiazole analogues of alpha-tocopherol (NBD-alpha-Tocs;lambda(ex) = 468 nm, lambda(em) = 527 nm) have been made previously to aid study of the intracellular location and transfer of vitamin E. Howe...
A mild platinum-catalyzed oxidative dehydrogenation of alpha,beta-C(sp(3))-H bonds of tertiary amines in the presence of ambient oxygen is revealed, and the in situ formed enamines subsequently reacting with various nitr...
A cationic Au(I) complex catalyzed benzannulation of 3-alkoxy-1,5-enynes bridged by a cyclopropyl ring with a variety of nucleophiles is described. The reaction occurs selectively through a 6-endo-dig pathway to provide ...
A variety of N-alkyl-beta-aminodiselenides have been synthesized in high yield from sulfamidates under mild reaction conditions using potassium selenocyanate and benzyltriethylammonium tetrathiomolybdate ([BnNEt3](2)MoS4...
A family of heterocyclic thiosemicarbazone dyes (1-9) linked to different furan, thiazole, (bi)thiophene, and arylthiophene pi-conjugated bridges were synthesized in good yields, and their response toward anions was stud...
The reaction of substituted glycolurils or a glycoluril dimer with a dialdehyde (o-phthalaldehyde) delivers S-shaped dimers and an S-shaped tetramer selectively. A combination of X-ray crystallography, PM3 calculations, ...
Two different mixture synthesis routes have been used to make the four stereoisomers of petrocortyne A. A first quick and dirty route provided a mixture of the four isomers in nonselective fashion. Mosher and 2-naphthylm...
From three basidiomycetes, Xeromphalina sp., Stereum sp., and Pleurocybella porrigens, six triquinane sesquiterpenes with unprecendented modifications and a rearranged sesquiterpene related to coriolin C have been isolat...
A novel four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and Cs2CO3 in ethylene glycol under microwave heating. The reaction proceeds at fast rate...
DMF (N,N-dimethylformamide)/KOH was found to be an efficient hydrogen source in the Pd(OAc)(2)-catalyzed transfer semihydrogenation of various functionalized internal alkynes to afford cis-alkenes in good to high yields ...
Quantum chemical calculations (OPBE/6-311++G(d,p)) have been performed to uncover the electronic factors that govern reactivity in the prototypical SNAr reaction. It was found that intrinsic nucleophilicity-expressed as ...
Carbon dioxide can be used as a convenient carbonylating agent in the synthesis of 2-oxazolidinones, 2-oxazinones, and cyclic ureas. The transient carbamate anion generated by treating a primary or secondary amine group ...
Novel reaction of tetranitromethane (TNM) with electrophilic alkenes in the presence of triethylamine yielding substituted 3-nitroisoxazoles was found and studied. Triethylamine increases the reactivity of TNM toward ele...