- Practical Synthesis of a Vanilloid Receptor-1 Antagonist.
[作者:Thiel, Oliver R.;Bernard, Charles;King, Tony;Dilmeghani-Seran, Mina;Bostick, Tracy;Larsen, Robert D.;Faul, Margaret M.;,期刊:Journal of Organic Chemistry, 页码:3508-3515 , 文章类型: 研究论文,,卷期:2008年73-9]
- (Heterocyclic Compounds (More Than One Hetero Atom)) Section Small mol. TRPV1 antagonists have been a recent focus in the search for pain treatment agents. A practical and scalable synthesis of AMG 628 (I), a bis-substi...
- A New Facile Approach to the Synthesis of 3-Methylthio-Substituted Furans, Pyrroles, Thiophenes, and Related Derivatives.
[作者:Yin, Guodong;Wang, Zihua;Chen, Aihua;Gao, Meng;Wu, Anxin;Pan, Yuanjiang;,期刊:Journal of Organic Chemistry, 页码:3377-3383 , 文章类型: 研究论文,,卷期:2008年73-9]
- 2-(Methylthio)-1,4-diaryl-2-butene-1,4-dione (I) are prepd. from readily available aryl Me ketones in the presence of copper(II) oxide, iodine, and DMSO. The success of the cross-coupling reaction of 4-chloroacetophenon...
- Design and Effective Synthesis of the First 4-Aza-2,3-didehydropodophyllotoxin Rigid Aminologue: A N-Methyl-4-[(3,4,5-trimethoxyphenyl)amino)]-1,2-dihydroquinoline-lacton e.
[作者:Labruere, Raphael;Helissey, Philippe;Desbene-Finck, Stephanie;Giorgi-Renault, Sylviane;,期刊:Journal of Organic Chemistry, 页码:3642-3645 , 文章类型: 研究论文,,卷期:2008年73-9]
- The first N1-alkyl-4-amino-1,2-dihydroquinoline-lactone I has been prepd. by a five-step sequence in a 51% overall yield via the corresponding furo[3,4-b]quinolin-1(3H)-one. A new practical synthesis of this intermediat...
- Novel diastereoselective synthesis of bicyclic b-lactams through radical cyclization and their reduction toward 2-(1-alkoxy-2-hydroxyethyl)piperidines and 2-(1-alkoxy-2-hydroxyethyl)azepanes. [Erratum to document cited in CA148:331451].
[作者:Leemans, Erika;D'Hooghe, Matthias;Dejaegher, Yves;Toernroos, Karl W.;De Kimpe, Norbert;,期刊:Journal of Organic Chemistry, 页码:3666-3666 , 文章类型: 研究论文,,卷期:2008年73-9]
- On page 1426, in Scheme 6, in transition states TTS 3 and TTS 4, the geometry of the double bond was indicated erroneously as Z; The correct scheme is provided.
- Dissociative Protonation and Proton Transfers: Fragmentation of a,b-Unsaturated Aromatic Ketones in Mass Spectrometry.
[作者:Hu, Nan;Tu, Ya-Ping;Liu, Yaqin;Jiang, Kezhi;Pan, Yuanjiang;,期刊:Journal of Organic Chemistry, 页码:3369-3376 , 文章类型: 研究论文,,卷期:2008年73-9]
- In mass spectrometry of the a,b-unsatd. arom. ketones, Ph-CO-CH=CH-Ph', losses of a benzene from the two ends and elimination of a styrene are the three major fragmentation reactions of the protonated mols. When the ket...
- Nonbonded, Attractive Cation-p Interactions in Azide-Mediated Asymmetric Ring Expansion Reactions.
[作者:Katz, Christopher E.;Ribelin, Timothy;Withrow, Donna;Basseri, Yashar;Manukyan, Anna K.;Bermudez, Amy;Nuera, Christian G.;Day, Victor W.;Powell, Douglas R.;Poutsma, Jennifer L.;Aube, Jeffrey;,期刊:Journal of Organic Chemistry, 页码:3318-3327 , 文章类型: 研究论文,,卷期:2008年73-9]
- The influence of attractive, nonbonded interactions on the reactions of 1,2- and 1,3-hydroxyalkyl azides with ketones has been investigated through exptl. and computational means. A series of 1,3-hydroxyalkyl azides bea...
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