【文章名】Design and Effective Synthesis of the First 4-Aza-2,3-didehydropodophyllotoxin Rigid Aminologue: A N-Methyl-4-[(3,4,5-trimethoxyphenyl)amino)]-1,2-dihydroquinoline-lacton e.
Design and Effective Synthesis of the First 4-Aza-2,3-didehydropodophyllotoxin Rigid Aminologue: A N-Methyl-4-[(3,4,5-trimethoxyphenyl)amino)]-1,2-dihydroquinoline-lacton e.
[摘要]：The first N1-alkyl-4-amino-1,2-dihydroquinoline-lactone I has been prepd. by a five-step sequence in a 51% overall yield via the corresponding furo[3,4-b]quinolin-1(3H)-one. A new practical synthesis of this intermediate was carried out using versatile, com. available starting materials and constitutes the shortest and highest yielding route. These synthetic pathways could be widened with a view toward the prepn. of different substituted derivs., which could be considered as rigid aminologues of 4-aza-2,3-didehydropodophyllotoxins.
