个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共40条记录   Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials [作者：ZHANG YIQUN; CLARK JULIE A; CONNELLY MICHELE C; ZHU FANGYI; MIN JAEKI; GUIGUEMDE W ARMAND; PRADHAN ANUPAM; IYER LALITHA; FURIMSKY ANNA; GOW JASON; PARMAN TOUFAN; EL MAZOUNI FARAH; PHILLIPS MARGARET A; KYLE DENNIS E; MIRSALIS JON; GUY R KIPLIN,期刊：Journal of Medicinal Chemistry, 页码：4205-4219 , 文章类型： Article，,卷期：2012年55-9] Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multidrug-resist... Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure-Activity Relationships, and Pharmacokinetics [作者：NDUNGU J MAINA; KRUMM STEFANIE A; YAN DAN; ARRENDALE RICHARD F; REDDY G PRABHAKAR; EVERS TAYLOR; HOWARD RANDY; NATCHUS MICHAEL G; SAINDANE MANOHAR T; LIOTTA DENNIS C; PLEMPER RICHARD K; SNYDER JAMES P; SUN AIMING,期刊：Journal of Medicinal Chemistry, 页码：4220-4230 , 文章类型： Article，,卷期：2012年55-9] The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric morbidity and mortality worldwide. In an effort to provide therapeutic treatments for improved measles management, we prev... In Vitro and in Vivo Trypanosomicidal Activity of Pyrazole-Containing Macrocyclic and Macrobicyclic Polyamines: Their Action on Acute and Chronic Phases of Chagas Disease [作者：SANCHEZMORENO MANUEL; MARIN CLOTILDE; NAVARRO PILAR; LAMARQUE LAURENT; GARCIAESPANA ENRIQUE; MIRANDA CARLOS; HUERTAS OSCAR; OLMO FRANCISCO; GOMEZCONTRERAS FERNANDO; PITARCH JAVIER; ARREBOLA FRANCISCO,期刊：Journal of Medicinal Chemistry, 页码：4231-4243 , 文章类型： Article，,卷期：2012年55-9] The in vitro and in vivo anti-Trypanosoma cruzi activity of the pyrazole-containing macrobicyclic polyamine 1 and N-methyl- and N-benzyl-substituted monocyclic polyamines 2 and 3 was studied. Activity against both the ac... Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents [作者：NAGLE ADVAIT; WU TAO; KUHEN KELLI; GAGARING KERSTIN; BORBOA RACHEL; FRANCEK CAROLINE; CHEN ZHONG; PLOUFFE DAVID; LIN XUENA; CALDWELL CHRISTOPHER; EK JARED; SKOLNIK SUZANNE; LIU FENGHUA; WANG JIANLING; CHANG JONATHAN; LI CHUN; LIU BO; HOLLENBECK THOMAS; TUNTLAND TOVE; ISBELL JOHN; CHUAN TIFFANY; ALPER PHILIP B; FISCHLI CHRISTOPH; BRUN RETO; LAKSHMINARAYANA SURESH B; ROTTMANN MATTHIAS; DIAGANA THIERRY T; WINZELER ELIZABETH A; GLYNNE RICHARD; TULLY DAVID C; CHATTERJEE ARNAB K,期刊：Journal of Medicinal Chemistry, 页码：4244-4273 , 文章类型： Article，,卷期：2012年55-9] On the basis of the initial success of optimization of a novel series of imidazolopiperazines, a second generation of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial proper... Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors [作者：LALONDE JUDITH M; KWON YOUNG DO; JONES DAVID M; SUN ALEXANDER W; COURTER JOEL R; SOETA TAKAHIRO; KOBAYASHI TOYOHARU; PRINCIOTTO AMY M; WU XUELING; SCHOEN ARNE; FREIRE ERNESTO; KWONG PETER D; MASCOLA JOHN R; SODROSKI JOSEPH; MADANI NAVID; SMITH AMOS B III,期刊：Journal of Medicinal Chemistry, 页码：4382-4396 , 文章类型： Article，,卷期：2012年55-9] Cellular infection by HIV-1 is initiated with a binding event between the viral envelope glycoprotein gp120 and the cellular receptor protein CD4. The CD4-gp120 interface is dominated by two hotspots: a hydrophobic gp120... High DNA Affinity of a Series of Peptide Linked Diaromatic Guanidinium-like Derivatives [作者：NAGLE PADRAIC S; RODRIGUEZ FERNANDO; BINH NGUYEN; WILSON W DAVID; ROZAS ISABEL,期刊：Journal of Medicinal Chemistry, 页码：4397-4406 , 文章类型： Article，,卷期：2012年55-9] In this paper we report the design and synthesis of a new family of asymmetric peptide linked diaromatic dications as potent DNA minor groove binders. These peptide-linked compounds, with a linear core, displayed a much ... Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3 alpha [作者：LO MONTE FABIO; KRAMER THOMAS; GU JIAMIN; ANUMALA UPENDRA RAO; MARINELLI LUCIANA; LA PIETRA VALERIA; NOVELLINO ETTORE; FRANCO BENEDICTE; DEMEDTS DAVID; VAN LEUVEN FRED; FUERTES ANA; MANUEL DOMINGUEZ JUAN; PLOTKIN BATYA; ELDARFINKELMAN HAGIT; SCHMIDT BORIS,期刊：Journal of Medicinal Chemistry, 页码：4407-4424 , 文章类型： Article，,卷期：2012年55-9] The glycogen synthase kinase-3 (GSK-3) has been linked to the pathogenesis of colorectal cancer, diabetes, cardiovascular disease, acute myeloid leukemia (AML), and Alzheimer's disease (AD). The debate on the respective ... Allosteric Inhibition of Cobalt Binding to Albumin by Fatty Acids: Implications for the Detection of Myocardial Ischemia [作者：LU JIN; STEWART ALAN J; SADLER PETER J; PINHEIRO TERESA J T; BLINDAUER CLAUDIA A,期刊：Journal of Medicinal Chemistry, 页码：4425-4430 , 文章类型： Article，,卷期：2012年55-9] The biomarker "ischemia-modified albumin" (IMA), measured by the albumin-cobalt-binding assay (ACB assay), is the only FDA-approved biomarker for early diagnosis of myocardial ischemia. On the basis of the hypothesis tha...