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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Design and Characterization of Optimized Adenosine A(2A)/A(1) Receptor Antagonists for the Treatment of Parkinson's Disease [作者：SHOOK BRIAN C; RASSNICK STEFANIE; WALLACE NATHANIEL; CROOKE JEFFREY; AULT MARK; CHAKRAVARTY DEVRAJ; BARBAY J KENT; WANG AIHUA; POWELL MARK T; LEONARD KRISTI; ALFORD VERNON; SCANNEVIN ROBERT H; CARROLL KAREN; LAMPRON LISA; WESTOVER LORI; LIM HENGKEANG; RUSSELL RONALD; BRANUM SHAWN; WELLS KENNETH M; DAMON SANDRA; YOUELLS SCOTT; LI XUN; BEAUCHAMP DEREK A; RHODES KENNETH; JACKSON PAUL F,期刊：Journal of Medicinal Chemistry, 页码：1402-1417 , 文章类型： Article，,卷期：2012年55-3] The design and characterization of two, dual adenosine A(2A)/A(1) receptor antagonists in several animal models of Parkinson's disease is described. Compound 1 was previously reported as a potential treatment for Parkins... Synthesis and Toxicopharmacological Evaluation of m-Hydroxymexiletine, the First Metabolite of Mexiletine More Potent Than the Parent Compound on Voltage-Gated Sodium Channels [作者：CATALANO ALESSIA; DESAPHY JEANFRANCOIS; LENTINI GIOVANNI; CAROCCI ALESSIA; DI MOLA ANTONIA; BRUNO CLAUDIO; CARBONARA ROBERTA; DE PALMA ANNALISA; BUDRIESI ROBERTA; GHELARDINI CARLA; PERRONE MARIA GRAZIA; COLABUFO NICOLA ANTONIO; CAMERINO DIANA CONTE; FRANCHINI CARLO,期刊：Journal of Medicinal Chemistry, 页码：1418-1422 , 文章类型： Article，,卷期：2012年55-3] The first synthesis of m-hydroxymexiletine (MHM) has been accomplished. MHM displayed hNav1.5 sodium channel blocking activity, and tests indicate it to be similar to 2-fold more potent than the parent mexiletine and to ... Drug Discovery Research Targeting the CXC Chemokine Receptor 4 (CXCR4) [作者：CHOI WONTAK; DUGGINENI SRINIVAS; XU YAN; HUANG ZIWEI; AN JING,期刊：Journal of Medicinal Chemistry, 页码：977-994 , 文章类型： Article，,卷期：2012年55-3] Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal [作者：RODRIGUES TIAGO; PRUDENCIO MIGUEL; MOREIRA RUI; MOTA MARIA M; LOPES FRANCISCA,期刊：Journal of Medicinal Chemistry, 页码：995-1012 , 文章类型： Article，,卷期：2012年55-3]